Lifestyle Management of Diabetes: Implications for the Bone-Vascular Axis

Overview

Journal Curr Diab Rep

Publisher Current Science

Specialty Endocrinology

Date 2018 Aug 20

PMID 30121859

Citations 6

Authors

Silvia Pieralice

Francesca Vigevano

Rossella Del Toro

Nicola Napoli

Ernesto Maddaloni

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: To describe the main pathways involved in the interplay between bone and cardiovascular disease and to highlight the possible impact of physical activity and medical nutrition therapy on the bone-vascular axis.

Recent Findings: Diabetes increases the risk of both cardiovascular disease and bone fragility fractures, sharing common pathogenic pathways, including OPG/RANK/RANKL, the FGF23/Klotho axis, calciotropic hormones, and circulating osteogenic cells. This may offer new therapeutic targets for future treatment strategies. As lifestyle intervention is the cornerstone of diabetes treatment, there is potential for an impact on the bone-vascular axis. Evidence published suggests the bone-vascular axis encompasses key pathways for cardiovascular disease. This, along with studies showing physical activity plays a crucial role in the prevention of both bone fragility and cardiovascular disease, suggests that lifestyle intervention incorporating exercise and diet may be helpful in managing skeletal health decline in diabetes. Studies investigating the controversial role of high-fiber diet and dietary vitamin D/calcium on bone and cardiovascular health suggest an overall benefit, but further investigations are needed in this regard.

Citing Articles

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Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia.

Del Toro R, Palmese F, Feletti F, Zani G, Minguzzi M, Maddaloni E J Clin Med. 2023; 12(6).

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Adult-onset autoimmune diabetes.

Buzzetti R, Maddaloni E, Gaglia J, Leslie R, Wong F, Boehm B Nat Rev Dis Primers. 2022; 8(1):63.

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The role of RANKL and FGF23 in Assessing Bone Turnover in Type 2 Diabetic Patients.

Nita G, Nita O, Gherasim A, Arhire L, Herghelegiu A, Mihalache L Acta Endocrinol (Buchar). 2021; 17(1):51-59.

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