The Action of Various Vitamin D3 Metabolites on Calcium and Phosphorus Metabolism in Chick Embryo Calvariae

Overview

Journal Experientia

Specialty Science

Date 1986 May 15

PMID 3011491

Authors

R Brommage

L E Hart

H F DeLuca

Affiliations

Soon will be listed here.

Abstract

Chick embryos from vitamin D-deficient hens given physiological doses of 1,25-dihydroxyvitamin D3 or 24,25-dihydroxyvitamin D3 or both become severely hypocalcemic, hyperphosphatemic and fail to hatch as compared to those derived from hens given 25-hydroxyvitamin D3 or 24,25-difluoro-25-hydroxyvitamin D3. Calvariae from the former contain less mineral and on incubation in vitro produce significantly lower calcium and higher phosphate concentration in the medium than do the calvariae derived from the embryos of hens supported on 25-hydroxyvitamin D3 or 24,24-difluoro-25-hydroxyvitamin D3.

References

Lebel D, Poirier G, BEAUDOIN A . A convenient method for the ATPase assay. Anal Biochem. 1978; 85(1):86-9. DOI: 10.1016/0003-2697(78)90277-4. View

Brommage R, Jarnagin K, DeLuca H, Yamada S, Takayama H . 1- but not 24-hydroxylation of vitamin D is required for skeletal mineralization in rats. Am J Physiol. 1983; 244(3):E298-304. DOI: 10.1152/ajpendo.1983.244.3.E298. View

Moriuchi S, DeLuca H . Metabolism of vitamin D3 in the chick embryo. Arch Biochem Biophys. 1974; 164(1):165-71. DOI: 10.1016/0003-9861(74)90018-6. View

Weinstein R, Underwood J, Hutson M, DeLuca H . Bone histomorphometry in vitamin D-deficient rats infused with calcium and phosphorus. Am J Physiol. 1984; 246(6 Pt 1):E499-505. DOI: 10.1152/ajpendo.1984.246.6.E499. View

Tanaka Y, Wichmann J, De Luca H, Kobayashi Y, Ikekawa N . Metabolism and binding properties of 24,24-difluoro-25-hydroxyvitamin D3. Arch Biochem Biophys. 1983; 225(2):649-55. DOI: 10.1016/0003-9861(83)90076-0. View

Endo H, Kiyoki M, Kawashima K, Naruchi T, Hashimoto Y . Vitamin D3 metabolites and PTH synergistically stimulate bone formation of chick embryonic femur in vitro. Nature. 1980; 286(5770):262-4. DOI: 10.1038/286262a0. View

Underwood J, DeLuca H . Vitamin D is not directly necessary for bone growth and mineralization. Am J Physiol. 1984; 246(6 Pt 1):E493-8. DOI: 10.1152/ajpendo.1984.246.6.E493. View

Hart L, DeLuca H . Effect of vitamin D3 metabolites on calcium and phosphorus metabolism in chick embryos. Am J Physiol. 1985; 248(3 Pt 1):E281-5. DOI: 10.1152/ajpendo.1985.248.3.E281. View

NARBAITZ R . Response of shell-less cultured chick embryos to exogenous parathyroid hormone and 1,25-dihydroxycholecalciferol. Gen Comp Endocrinol. 1979; 37(4):440-2. DOI: 10.1016/0016-6480(79)90023-6. View

10.

NARBAITZ R, Tolnai S . Effects produced by the administration of high doses of 1,25-dihydroxycholecalciferol to the chick embryo. Calcif Tissue Res. 1978; 26(3):221-6. DOI: 10.1007/BF02013262. View

11.

Ameenuddin S, Sunde M, DeLuca H, Ikekawa N, Kobayashi Y . Support of embryonic chick survival by vitamin D metabolites. Arch Biochem Biophys. 1983; 226(2):666-70. DOI: 10.1016/0003-9861(83)90336-3. View

12.

Rosen V, Clark N . Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on embryonic chick bone in organ culture. J Exp Zool. 1982; 224(1):97-101. DOI: 10.1002/jez.1402240110. View

13.

Tanaka Y, DeLuca H, Schnoes H, Ikekawa N, Kobayashi Y . 24,24-difluoro-1,25-dihydroxyvitamin D3: in vitro production, isolation, and biological activity. Arch Biochem Biophys. 1980; 199(2):473-8. DOI: 10.1016/0003-9861(80)90304-5. View

14.

Tanaka Y, DeLuca H, Kobayashi Y, Taguchi T, Ikekawa N, Morisaki M . Biological activity of 24,24-difluoro-25-hydroxyvitamin D3. Effect of blocking of 24-hydroxylation on the functions of vitamin D. J Biol Chem. 1979; 254(15):7163-7. View

15.

Hart L, DeLuca H, Yamada S, Takayama H . Hydroxylation of carbon-24 of 25-hydroxycholecalciferol is not necessary for normal embryonic development in chickens. J Nutr. 1984; 114(11):2059-65. DOI: 10.1093/jn/114.11.2059. View