Design, Synthesis and Bioactivities of Phenithionate Analogues or Derivatives for Anti-schistosomiasis

Overview

Journal Medchemcomm

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Aug 16

PMID 30108926

Citations 1

Authors

Shiyang Zhou

Gangliang Huang

Affiliations

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Abstract

A novel series of phenithionate analogues or derivatives were designed and synthesized using phenithionate as the lead compound, and their bioactivities were studied. Their structures were confirmed by H NMR, C NMR, HR-ESI-MS, and elemental analysis, respectively. The results of inhibitory activity measurement proved that compounds , , , , and had a better inhibitory effect on larva and imago schistosoma. Among them, the inhibitory activity of compound for larva schistosoma was IC = 5.21 ± 0.04 μg mL, and for imago schistosoma it was IC = 6.35 ± 0.08 μg mL. Moreover, the experimental results of anti-schistosomiasis activity measurement showed that they had good anti-schistosomiasis activity. Therefore, these compounds had better drugability.

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