Thiosemicarbazone-based Selective Proliferation Inactivators Inhibit Gastric Cancer Cell Growth, Invasion, and Migration

Overview

Journal Medchemcomm

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Aug 16

PMID 30108734

Citations 3

Authors

Biao Hu

Bo Wang

Bing Zhao

Qian Guo

Zhong-Hua Li

Xin-Hui Zhang

Guang-Yao Liu

Ying Liu

Ying Tang

Fan Luo

Ya Du

Ya-Xin Chen

Li-Ying Ma

Hong-Min Liu

Affiliations

Soon will be listed here.

Abstract

A series of novel thiosemicarbazone derivatives were synthesized and evaluated for their antiproliferative activity against several selected tumor cell lines of different origins using the MTT assay. The preliminary results indicated that the MGC-803 cell line was remarkably sensitive to all the synthesized compounds. Among this series, compound showed the best inhibitory activity with an IC value of 0.93 μM (about 10-fold more potent than ) against MGC-803. Further mechanism studies revealed that compound could obviously inhibit the proliferation of MGC-803 cells by inducing apoptosis and arresting the cell cycle at the S phase. Compound also showed marked inhibition of cell migration and invasion, without significant cytotoxicity against gastric epithelial immortalized GES-1 cells.

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