Association Between MiR-124-1 Rs531564 Polymorphism and Risk of Cancer: An Updated Meta-analysis of Case-control Studies

Overview

Journal EXCLI J

Specialty Biology

Date 2018 Aug 16

PMID 30108465

Citations 8

Authors

Abdolkarim Moazeni-Roodi

Mohammad Hashemi

Affiliations

Soon will be listed here.

Abstract

Many studies examined the association between miR-124-1 rs531564 polymorphism and the risk of some human cancers, but the findings remain controversial. This update meta-analysis aimed to validate the association between rs531564 polymorphism of miR-124-1 and cancer risk. Eligible studies including 6,502 cancer cases and 7,213 controls were documented by searching Web of Science, PubMed, Scopus, and Google scholar databases. Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were estimated to quantitatively evaluate the association between rs531564 variant and cancer risk. The results indicated that rs531564 variant significantly decreased the risk of cancer in homozygous codominant (OR=0.54, 95 % CI=0.43-0.69, p<0.00001, GG vs CC), dominant (OR=0.84, 95 % CI=0.72-0.99, p=0.03, CG+GG vs CC), recessive (OR=0.65, 95 % CI=0.54-0.78, p<0.00001, GG vs CG+CC), and allele (OR=0.84, 95 % CI=0.73-0.96, p=0.008, G vs C) genetic model. Stratified analysis by cancer type revealed that rs531564 variant was associated with gastric cancer, cervical cancer, esophageal squamous cell carcinoma and colorectal cancer risk. In summary, the findings of this meta-analysis support an association between miR-124-1 rs531564 polymorphism and cancer risk. Larger and well-designed studies are required to estimate this association in detail.

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References

Yin J, Wang X, Zheng L, Shi Y, Wang L, Shao A . Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population. PLoS One. 2013; 8(11):e80570. PMC: 3832359. DOI: 10.1371/journal.pone.0080570. View

Shen B, Zhang Y, Yu S, Yuan Y, Zhong Y, Lu J . MicroRNA-339, an epigenetic modulating target is involved in human gastric carcinogenesis through targeting NOVA1. FEBS Lett. 2015; 589(20 Pt B):3205-11. DOI: 10.1016/j.febslet.2015.09.009. View

Omrani M, Hashemi M, Eskandari-Nasab E, Hasani S, Mashhadi M, Arbabi F . hsa-mir-499 rs3746444 gene polymorphism is associated with susceptibility to breast cancer in an Iranian population. Biomark Med. 2014; 8(2):259-67. DOI: 10.2217/bmm.13.118. View

Xiong X, Cheng J, Liu X, Tang S, Luo X . [Correlation analysis between miR-124 rs531564 polymorphisms and susceptibility to cervical cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2014; 34(2):210-3. View

Zhang J, Huang X, Xiao J, Yang Y, Zhou Y, Wang X . Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations. PLoS One. 2014; 9(6):e100055. PMC: 4063769. DOI: 10.1371/journal.pone.0100055. View

Jin H, Li Q, Cao F, Wang S, Wang R, Wang Y . miR-124 Inhibits Lung Tumorigenesis Induced by K-ras Mutation and NNK. Mol Ther Nucleic Acids. 2017; 9:145-154. PMC: 5633347. DOI: 10.1016/j.omtn.2017.09.005. View

Frazer K, Ballinger D, Cox D, Hinds D, Stuve L, Boudreau A . A second generation human haplotype map of over 3.1 million SNPs. Nature. 2007; 449(7164):851-61. PMC: 2689609. DOI: 10.1038/nature06258. View

He J, Zhang W, Zhou Q, Zhao T, Song Y, Chai L . Low-expression of microRNA-107 inhibits cell apoptosis in glioma by upregulation of SALL4. Int J Biochem Cell Biol. 2013; 45(9):1962-73. DOI: 10.1016/j.biocel.2013.06.008. View

Ma F, Zhang P, Lin D, Yu D, Yuan P, Wang J . There is no association between microRNA gene polymorphisms and risk of triple negative breast cancer in a Chinese Han population. PLoS One. 2013; 8(3):e60195. PMC: 3608627. DOI: 10.1371/journal.pone.0060195. View

10.

Wu H, Zhang J . miR-124 rs531564 polymorphism influences genetic susceptibility to cervical cancer. Int J Clin Exp Med. 2015; 7(12):5847-51. PMC: 4307565. View

11.

Skjefstad K, Johannessen C, Grindstad T, Kilvaer T, Paulsen E, Pedersen M . A gender specific improved survival related to stromal miR-143 and miR-145 expression in non-small cell lung cancer. Sci Rep. 2018; 8(1):8549. PMC: 5986811. DOI: 10.1038/s41598-018-26864-w. View

12.

Wu F, Li M, You W, Ji Y, Cui X, Hu J . A Genetic Variant in miR-124 Decreased the Susceptibility to Esophageal Squamous Cell Carcinoma in a Chinese Kazakh Population. Genet Test Mol Biomarkers. 2017; 22(1):29-34. DOI: 10.1089/gtmb.2017.0115. View

13.

Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre M . The Global Burden of Cancer 2013. JAMA Oncol. 2015; 1(4):505-27. PMC: 4500822. DOI: 10.1001/jamaoncol.2015.0735. View

14.

Fang C, Zeng H, Li A, Xu X, Long X . Association of the pri- rs531564 polymorphism with cancer risk: A meta-analysis. Mol Clin Oncol. 2015; 3(4):892-896. PMC: 4486815. DOI: 10.3892/mco.2015.547. View

15.

Yuan L, Li S, Zhou Q, Wang D, Zou D, Shu J . MiR-124 inhibits invasion and induces apoptosis of ovarian cancer cells by targeting programmed cell death 6. Oncol Lett. 2018; 14(6):7311-7317. PMC: 5754840. DOI: 10.3892/ol.2017.7157. View

16.

Ying H, Peng H, He B, Pan Y, Wang F, Sun H . MiR-608, pre-miR-124-1 and pre-miR26a-1 polymorphisms modify susceptibility and recurrence-free survival in surgically resected CRC individuals. Oncotarget. 2016; 7(46):75865-75873. PMC: 5342784. DOI: 10.18632/oncotarget.12422. View

17.

Danesh H, Hashemi M, Bizhani F, Hashemi S, Bahari G . Association study of miR-100, miR-124-1, miR-218-2, miR-301b, miR-605, and miR-4293 polymorphisms and the risk of breast cancer in a sample of Iranian population. Gene. 2018; 647:73-78. DOI: 10.1016/j.gene.2018.01.025. View

18.

Zhou Y, Du W, Chen G, Ruan J, Xu S, Zhou F . Association analysis of genetic variants in microRNA networks and gastric cancer risk in a Chinese Han population. J Cancer Res Clin Oncol. 2012; 138(6):939-45. DOI: 10.1007/s00432-012-1164-8. View

19.

Gao X, Wang H, Zhang S, Wang M, Zhu Z . Pri-miR-124 rs531564 polymorphism and colorectal cancer risk. Sci Rep. 2015; 5:14818. PMC: 4589757. DOI: 10.1038/srep14818. View

20.

Calin G, Sevignani C, Dumitru C, Hyslop T, Noch E, Yendamuri S . Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A. 2004; 101(9):2999-3004. PMC: 365734. DOI: 10.1073/pnas.0307323101. View