The Vitamin K Metabolome in Chronic Kidney Disease

Overview

Journal Nutrients

Date 2018 Aug 15

PMID 30103541

Citations 7

Authors

Mandy E Turner

Michael A Adams

Rachel M Holden

Affiliations

Soon will be listed here.

Abstract

The purpose of this review is to summarize the research to date on the impact of chronic kidney disease (CKD) on the vitamin K metabolome. Vitamin K-dependent proteins contribute to cardiovascular disease (CVD) prevention via the prevention of ectopic mineralization. Sub-clinical vitamin K deficiency is common in CKD patients, and evidence suggests that it may contribute to the CVD burden in this population. Research from animal models suggests that CKD alters tissue measures of the two predominant forms of vitamin K: K and MK-4. The expression and/or activity of enzymes that regulate the recycling of vitamin K and the carboxylation of vitamin K-dependent proteins also appear to be altered in CKD. Evidence suggests that statins, a common pharmaceutical prescribed to CKD patients to prevent cardiovascular events, may impact the metabolism of vitamin K and therefore contribute to its relative inefficiency at preventing CVD in this population as kidney disease progresses. Human research on the tissue vitamin K metabolome in CKD patients is lacking.

Citing Articles

Vitamin K for Vascular Calcification in Kidney Patients: Still Alive and Kicking, but Still a Lot to Learn.

Neofytou I, Stamou A, Demopoulos A, Roumeliotis S, Zebekakis P, Liakopoulos V Nutrients. 2024; 16(12).

PMID: 38931153 PMC: 11206649. DOI: 10.3390/nu16121798.

Vitamin K supplementation impact in dialysis patients: a systematic review and meta-analysis of randomized trials.

Andrian T, Stefan A, Nistor I, Covic A Clin Kidney J. 2023; 16(12):2738-2749.

PMID: 38046003 PMC: 10689161. DOI: 10.1093/ckj/sfad255.

Biological Role of Vitamin K-With Particular Emphasis on Cardiovascular and Renal Aspects.

Stepien A, Koziarska-Rosciszewska M, Rysz J, Stepien M Nutrients. 2022; 14(2).

PMID: 35057443 PMC: 8780346. DOI: 10.3390/nu14020262.

Vitamin K and D Supplementation and Bone Health in Chronic Kidney Disease-Apart or Together?.

Zieminska M, Sieklucka B, Pawlak K Nutrients. 2021; 13(3).

PMID: 33804453 PMC: 7999920. DOI: 10.3390/nu13030809.

Role of emerging vitamin K‑dependent proteins: Growth arrest‑specific protein 6, Gla‑rich protein and periostin (Review).

Xiao H, Chen J, Duan L, Li S Int J Mol Med. 2021; 47(3).

PMID: 33448308 PMC: 7834955. DOI: 10.3892/ijmm.2020.4835.

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