Chemical Synthesis of Rare, Deoxy-Amino Sugars Containing Bacterial Glycoconjugates As Potential Vaccine Candidates

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Aug 15

PMID 30103434

Citations 9

Authors

Archanamayee Behera

Suvarn S Kulkarni

Affiliations

Soon will be listed here.

Abstract

Bacteria often contain rare deoxy amino sugars which are absent in the host cells. This structural difference can be harnessed for the development of vaccines. Over the last fifteen years, remarkable progress has been made toward the development of novel and efficient protocols for obtaining the rare sugar building blocks and their stereoselective assembly to construct conjugation ready bacterial glycans. In this review, we discuss the total synthesis of a variety of rare sugar containing bacterial glycoconjugates which are potential vaccine candidates.

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