Induction of C-sis MRNA and Activity Similar to Platelet-derived Growth Factor by Transforming Growth Factor Beta: a Proposed Model for Indirect Mitogenesis Involving Autocrine Activity

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1986 Apr 1

PMID 3010310

Citations 110

Authors

E B Leof

J A Proper

A S Goustin

G D Shipley

P E DiCorleto

H L Moses

Affiliations

Soon will be listed here.

Abstract

Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor beta resulted in an early induction of c-sis mRNA. The increase in c-sis mRNA was followed by a corresponding increase in protein similar to platelet-derived growth factor (PDGF) in the culture medium. In addition, PDGF-regulated genes (c-fos and c-myc) were stimulated by transforming growth factor beta with delayed kinetics relative to that seen in other cell systems with direct PDGF stimulation. A model is proposed in which the monolayer mitogenicity of transforming growth factor beta is mediated by the induction of c-sis and PDGF and the subsequent autocrine stimulation of c-fos, c-myc, and other PDGF-inducible genes.

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