Class I Histocompatibility Antigens and Insulin Receptors: Evidence for Interactions

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1986 May 1

PMID 3010300

Citations 21

Authors

M L Phillips

M L MOULE

T L Delovitch

C C Yip

Affiliations

Soon will be listed here.

Abstract

We provide evidence for an interaction between mouse class I major histocompatibility complex antigens and insulin receptors. Antibodies against class I but not class II major histocompatibility complex antigens immunoprecipitate photoaffinity-labeled hepatic insulin receptors. Haplotype specificity is demonstrated by reciprocal precipitation using anti-class I antibodies and three strains of mice. Antibodies against the 45-kDa products of either the H-2K or H-2D locus and rabbit anti-mouse beta 2-microglobulin antibodies were shown to precipitate insulin receptors. We also demonstrate the specific binding of 125I-labeled insulin and 125I-labeled epidermal growth factor, but not 125I-labeled glucagon or 125I-labeled atrial natriuretic factor, to solubilized plasma membranes immunoprecipitated with anti-H-2K antibody. These observations suggest a specific interaction between class I major histocompatibility complex antigens and certain hormone receptors.

Citing Articles

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MHC class I limits hippocampal synapse density by inhibiting neuronal insulin receptor signaling.

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