Utility of CT Imaging in a Novel Form of High-dose-rate Intraoperative Breast Radiation Therapy

Overview

Journal J Med Imaging Radiat Oncol

Specialties Oncology
Radiology

Date 2018 Aug 14

PMID 30102019

Citations 5

Authors

Taryn E Hassinger

Timothy N Showalter

Anneke T Schroen

David R Brenin

Adam C Berger

Bruce Libby

Shayna L Showalter

Affiliations

Soon will be listed here.

Abstract

Introduction: Intraoperative radiation therapy (IORT) is an alternative to whole breast radiation following breast conserving surgery. Conventional breast IORT is limited by lack of cross-sectional imaging. In response, our institution developed Precision Breast IORT (PB-IORT) which utilizes intraoperative computed tomography (CT) images for confirmation of brachytherapy applicator placement and for treatment planning. The purpose of this study was to determine the utility of CT imaging in PB-IORT in the first 103 patients treated in two prospective clinical trials.

Methods: We retrospectively reviewed the first 103 patients treated with PB-IORT. All patients underwent breast surgery and placement of a multi-lumen brachytherapy applicator. Patients had a CT scan followed by high-dose-rate (HDR) brachytherapy. Endpoints were the number of patients having more than one CT during PB-IORT and the number of treatment plans having image-based modifications.

Results: After initial CT scan, 27 patients (26.2%) had findings prompting surgical applicator adjustment. One patient underwent an additional scan to localize a biopsy clip and aid in excision to negative margin. Eighty-one patients (78.6%) had dosimetry modifications based on CT findings with 36 plans (35.0%) adjusted to protect the skin or chest wall and 45 plans (43.7%) to protect both the skin and chest wall.

Conclusions: Computed tomography findings prompted treatment alterations in the majority of patients treated with PB-IORT to enhance tissue conformity and to sculpt the radiation dose away from normal tissues. CT imaging is unique to PB-IORT. These findings suggest the potential clinical superiority of PB-IORT given its allowance for patient-specific alterations.

Citing Articles

First clinical application of image-guided intraoperative electron radiation therapy with real time intraoperative dose calculation in recurrent rectal cancer: technical procedure.

Roeder F, Fastner G, Fussl C, Sedlmayer F, Stana M, Berchtold J Radiat Oncol. 2023; 18(1):186.

PMID: 37950314 PMC: 10638784. DOI: 10.1186/s13014-023-02374-6.

A comparative study using time-driven activity-based costing in single-fraction breast high-dose rate brachytherapy: An integrated brachytherapy suite vs. decentralized workflow.

Squeo G, Lattimore C, Simone N, Suralik G, Dutta S, Schad M Brachytherapy. 2022; 21(3):334-340.

PMID: 35125328 PMC: 9149052. DOI: 10.1016/j.brachy.2021.12.006.

Effects of a novel form of intraoperative radiation therapy on quality of life among patients with early-stage breast cancer.

Lattimore C, Meneveau M, Petroni G, Varhegyi N, Squeo G, Showalter T Brachytherapy. 2022; 21(3):325-333.

PMID: 35120862 PMC: 9149037. DOI: 10.1016/j.brachy.2021.12.002.

Update on intraoperative radiotherapy for early-stage breast cancer.

Feng K, Meng X, Liu J, Xing Z, Zhang M, Wang X Am J Cancer Res. 2020; 10(7):2032-2042.

PMID: 32774999 PMC: 7407349.

Toxicity and cosmetic outcomes after treatment with a novel form of breast IORT.

Meneveau M, Petroni G, Varhegyi N, Hulse J, Schroen A, Brenin D Brachytherapy. 2020; 19(5):679-684.

PMID: 32571746 PMC: 7494626. DOI: 10.1016/j.brachy.2020.05.002.

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