Association of VEGFA Polymorphisms with Necrotizing Enterocolitis in Chinese Han Population

Overview

Journal Pediatr Neonatol

Publisher Elsevier

Specialty Pediatrics

Date 2018 Aug 14

PMID 30100520

Citations 5

Authors

Xiaoyan Gao

Fei Ma

Hu Hao

Yiheng Dai

Weidong Liu

Xin Xiao

Pingmin Gao

Sitao Li

Affiliations

Soon will be listed here.

Abstract

Background: To examine whether polymorphisms in the VEGFA gene lead to low VEGFA production in peripheral blood and increased risk of NEC in the Chinese Han population.

Material And Methods: Thirty NEC patients and 80 control subjects were enrolled. Six VEGFA single-nucleotide polymorphisms (SNPs) were performed using the SEQUENOM MassARRAY platform assay. The concentration of VEGFA in the plasma was measured using an enzyme-linked immunosorbent assay.

Results: The rs699947 and rs833061 VEGF-A SNPs were found to be associated with low plasma levels and high risk of NEC.

Conclusion: Our results suggested that, if validated in larger studies, screening for VEGFA SNPs and plasma levels might be useful as a risk factor for NEC in the future.

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