Changes in Platelet Morphology Indices in Relation to Duration of Disease and Glycemic Control in Children with Type 1 Diabetes Mellitus

Background: There is limited data on platelet alterations in children with type 1 diabetes mellitus (T1DM). We planned to study the effect of glycemic control and duration of T1DM on platelet morphology in children with T1DM.

Methods: We conducted an observational study on 260 children; 130 with T1DM (cases) and 130 healthy controls, in a tertiary care pediatric hospital. Platelet indices including Platelet count (PLT), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet-Large cell ratio (P-LCR), Plateletcrit (PCT) were measured, and their means were compared between cases and controls and various subgroups among the cases.

Results: The MPV, PDW and P-LCR were significantly higher (p < 0.05) in cases when compared to controls and in children with suboptimal glycemic control compared to optimal control. PLT was considerably lower in cases compared to controls. In children with new-onset T1DM, only PDW was significantly raised when compared to controls. MPV and P-LCR had a significant positive correlation with duration of T1DM.

Conclusions: Children with T1DM have altered morphological parameter(s) which progress over time. Poor glycemic control is a significant risk factor for abnormal platelet indices.