Enhancive and Suppressive Effects of Cytomegalovirus on Human Lymphocyte Responses in Vitro

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1986 Jun 1

PMID 3009895

Citations 7

Authors

B Wahren

P Ljungman

T Paulin

O Ringden

Affiliations

Soon will be listed here.

Abstract

Virus-specific lymphocyte proliferation in the presence of cytomegalovirus (CMV) without and with monocytes was studied in healthy persons. Three categories of lymphocyte response could be distinguished: seropositive low responders, naturally high responders, and lymphocyte populations responding well to CMV antigen in the presence of added CMV-incubated autologous monocytes. This latter category could be identified by preincubating autologous monocytes with CMV. CMV-seronegative persons were nonresponders. Early CMV antigens were produced in monocytes but not in lymphocytes by all CMV isolates. Infection of monocytes as detected by antibody to early viral protein did not appear to abort the antigen-presenting ability. The virus-specific responding lymphocytes were mainly of the T4+ phenotype. In contrast, addition of CMV to polyclonal mitogens significantly suppressed total lymphocyte DNA synthesis. CMV thus may have an enhanced virus-specific stimulatory effect on lymphocytes together with monocytes but a suppressive effect on the total lymphocyte population.

Citing Articles

Molecular biology and immunology of cytomegalovirus.

Griffiths P, Grundy J Biochem J. 1987; 241(2):313-24.

PMID: 3036059 PMC: 1147564. DOI: 10.1042/bj2410313.

Characteristics of the specific cell-mediated immune response in human immunodeficiency virus infection.

Wahren B, Biberfeld G, Moberg L, Sonnerborg A, Ljungman P, Werner A J Virol. 1987; 61(6):2017-23.

PMID: 3033328 PMC: 254211. DOI: 10.1128/JVI.61.6.2017-2023.1987.

Monocyte and iscom enhancement of cell-mediated response to cytomegalovirus.

Wahren B, NORDLUND S, Akesson A, Sundqvist V, Morein B Med Microbiol Immunol. 1987; 176(1):13-9.

PMID: 3029554 DOI: 10.1007/BF00189404.

The cellular immune response to cell-associated and cell-free cytomegalovirus (CMV) antigens after primary CMV-infection in non-immunocompromised hosts: development and maintenance of CMV-latency and its influence on immunocompetence.

Roenhorst H, Kallenberg C, The T Clin Exp Immunol. 1988; 74(3):326-32.

PMID: 2853014 PMC: 1542018.

Cytomegalovirus infection of peripheral blood mononuclear cells: effects on interleukin-1 and -2 production and responsiveness.

Kapasi K, Rice G J Virol. 1988; 62(10):3603-7.

PMID: 2843662 PMC: 253500. DOI: 10.1128/JVI.62.10.3603-3607.1988.

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