Management of a Case of High-risk Gastrointestinal Stromal Tumor in Rectum by Transanal Minimal Invasive Surgery

Overview

Journal World J Surg Oncol

Publisher Biomed Central

Specialties General Surgery
Oncology

Date 2018 Aug 13

PMID 30098596

Citations 9

Authors

Pramod Nepal

Shinichiro Mori

Yoshiaki Kita

Kan Tanabe

Kenji Baba

Yasuto Uchikado

Hiroshi Kurahara

Takaaki Arigami

Masahiko Sakoda

Kosei Maemura

Shoji Natsugoe

Affiliations

Soon will be listed here.

Abstract

Background: Rectal gastrointestinal stromal tumor (GIST) is a very rare tumor of gastrointestinal tract. Surgical management of rectal GIST requires special attention for preserving of anal and urinary functions. Transanal minimal invasive surgery (TAMIS) is a well-developed minimally invasive technique for local excision of benign and early malignant rectal tumors; however, the application of TAMIS for rectal GIST is rarely and inadequately reported. We report the novel application of TAMIS for rectal GIST with considerations for anal and urinary functions.

Case Presentation: A 67 years old female, who presented with history of per rectal bleeding, was diagnosed with submucosal GIST of 4.5 cm in diameter at right posterior wall of 7 cm from anal verge. Histology of biopsy showed abundant spindle-shaped cells arranged in bundles that were positive for CD34 and negative for C-Kit, desmin, smooth muscle actin (SMA), and S-100. The tumor was excised by TAMIS successfully. Final histopathology showed pT2 tumor with C-Kit positive and mitosis count 10 per 50 HPF. Postoperative period was uneventful, and she was discharged on adjuvant imatinib mesylate for 3 years.

Conclusion: TAMIS can be used safely in the management of rectal GIST after appropriate evaluation of tumor size, extent, location, and experience of operating surgeon.

Citing Articles

Advances of endoscopic and surgical management in gastrointestinal stromal tumors.

Yue L, Sun Y, Wang X, Hu W Front Surg. 2023; 10:1092997.

PMID: 37123546 PMC: 10130460. DOI: 10.3389/fsurg.2023.1092997.

Gastrointestinal Stromal Tumours (GIST) of the Rectum: A Systematic Review and Meta-Analysis.

Khan S, OSullivan N, Temperley H, Rausa E, Mehigan B, McCormick P Curr Oncol. 2023; 30(1):416-429.

PMID: 36661683 PMC: 9857930. DOI: 10.3390/curroncol30010034.

Recent Advancements in the Treatment of Rectal Gastrointestinal Stromal Tumor: In Era of Imatinib.

Qu H, Xu Z, Ren Y, Gong Z, Ju R, Zhang F Cancer Manag Res. 2022; 14:1141-1152.

PMID: 35321404 PMC: 8934706. DOI: 10.2147/CMAR.S352860.

Malignant Gastrointestinal Stromal Tumor of Rectum: A Case Report and Review of Literature.

Karthikeyan M, Kolandasamy C, Naganath Babu O Surg J (N Y). 2022; 8(1):e60-e64.

PMID: 35187230 PMC: 8850004. DOI: 10.1055/s-0042-1742778.

Correlation analysis of multi-slice computed tomography (MSCT) findings, clinicopathological factors, and prognosis of gastric gastrointestinal stromal tumors.

Xu D, Si G, He Q Transl Cancer Res. 2022; 9(3):1787-1794.

PMID: 35117526 PMC: 8798426. DOI: 10.21037/tcr.2020.02.26.

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