Altered Formation of the Iron Oxide Nanoparticle-biocorona Due to Individual Variability and Exercise

Overview

Journal Environ Toxicol Pharmacol

Date 2018 Aug 11

PMID 30096581

Citations 6

Authors

Lisa M Kobos

Sherleen Xue-Fu Adamson

Sheelagh Evans

Timothy P Gavin

Jonathan H Shannahan

Affiliations

Soon will be listed here.

Abstract

Nanoparticles (NPs), introduced into a biological environment, accumulate a coating of biomolecules or biocorona (BC). Although the BC has toxicological and pharmacological consequences, the effects of inter-individual variability and exercise on NP-BC formation are unknown. We hypothesized that NPs incubated in plasma form distinct BCs between individuals, and exercise causes additional intra-individual alterations. 20 nm iron oxide (FeO) NPs were incubated in pre- or post-exercise plasma ex vivo, and proteomics was utilized to evaluate BC components. Analysis demonstrated distinct BC formation between individuals, while exercise was found to enhance NP-BC complexity. Abundance differences of NP-BC proteins were determined between individuals and resulting from exercise. Differential human macrophage response was identified due to NP-BC variability. These findings demonstrate that individuals form unique BCs and that exercise influences NP-biomolecule interactions. An understanding of NP-biomolecule interactions is necessary for elucidation of mechanisms responsible for variations in human responses to NP exposures and/or nano-based therapies.

Citing Articles

Incubating Green Synthesized Iron Oxide Nanorods for Proteomics-Derived Motif Exploration: A Fusion to Deep Learning Oncogenesis.

Manzoor Y, Hasan M, Zafar A, Dilshad M, Ahmed M, Tariq T ACS Omega. 2023; 7(51):47996-48006.

PMID: 36591177 PMC: 9798745. DOI: 10.1021/acsomega.2c05948.

Modulation of Pulmonary Toxicity in Metabolic Syndrome Due to Variations in Iron Oxide Nanoparticle-Biocorona Composition.

Xia L, Alqahtani S, Ferreira C, Aryal U, Biggs K, Shannahan J Nanomaterials (Basel). 2022; 12(12).

PMID: 35745361 PMC: 9230893. DOI: 10.3390/nano12122022.

An Integrative Proteomic/Lipidomic Analysis of the Gold Nanoparticle Biocorona in Healthy and Obese Conditions.

Kobos L, Alqatani S, Ferreira C, Aryal U, Hedrick V, Sobreira T Appl In Vitro Toxicol. 2020; 5(3):150-166.

PMID: 32292798 PMC: 6768227. DOI: 10.1089/aivt.2019.0005.

Biocorona-induced modifications in engineered nanomaterial-cellular interactions impacting biomedical applications.

Kobos L, Shannahan J Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019; 12(3):e1608.

PMID: 31788989 PMC: 9567396. DOI: 10.1002/wnan.1608.

Analyzing the Interaction between Two Different Types of Nanoparticles and Serum Albumin.

Cristian R, Mohammad I, Mernea M, Sbarcea B, Trica B, Stan M Materials (Basel). 2019; 12(19).

PMID: 31569341 PMC: 6804176. DOI: 10.3390/ma12193183.

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