Cytotoxicological Pathways Induced After Nanoparticle Exposure: Studies of Oxidative Stress at the 'nano-bio' Interface

Overview

Journal Toxicol Res (Camb)

Publisher Oxford University Press

Date 2018 Aug 10

PMID 30090527

Citations 8

Authors

Henry Lujan

Christie M Sayes

Affiliations

Soon will be listed here.

Abstract

Nanotechnology is advancing rapidly; many industries are utilizing nanomaterials because of their remarkable properties. As of 2017, over 1800 "nano-enabled products" ( products that incorporate a nanomaterial feature and alter the product's performance) have been used to revolutionize pharmaceutical, transportation, and agriculture industries, just to name a few. As the number of nano-enabled products continues to increase, the risk of nanoparticle exposure to humans and the surrounding environment also increases. These exposures are usually classified as either or . The increased rate of potential nanoparticle exposure to humans has required the field of 'nanotoxicology' to rapidly screen for key biological, biochemical, chemical, or physical signals, signatures, or markers associated with specific toxicological pathways of injury within , , and models. One of the common goals of nanotoxicology research is to identify critical perturbed biological pathways that can lead to an adverse outcome. This review focuses on the most common toxicological pathways induced by nanoparticle exposure and provides insights into how these perturbations could aid in the development of nanomaterial specific adverse outcomes, inform nano-enabled product development, ensure safe manufacturing practices, promote product use, and avoid environmental health hazards.

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