Arylamine N-acetyltransferase 2 Polymorphisms and the Risk of Endometriosis

Overview

Journal Avicenna J Med Biotechnol

Specialty Biomedical Engineering

Date 2018 Aug 10

PMID 30090210

Citations 5

Authors

Diman Fayez

Kioomars Saliminejad

Shiva Irani

Koorosh Kamali

Toktam Memariani

Hamid Reza Khorram Khorshid

Affiliations

Soon will be listed here.

Abstract

Background: Human arylamine N-acetyltransferase 2 gene has a key role in xenobiotic metabolism through the conjugation of acetyl group to xenobiotic substances. has been suggested as a susceptibility factor in endometriosis; however, the results of studies have been controversial. In this study, the association of polymorphisms with susceptibility to endometriosis was evaluated in an Iranian population.

Methods: This is an association study and totally 141 women with diagnosis of endometriosis and 158 healthy women as control group were analyzed for gene polymorphisms (C481T, A803G, G857A and G590A) by PCR-RFLP methods.

Results: The 590 GA genotype was significantly lower (p=0.001; OR=0.42, 95% CI: 0.25-0.71) in the patients (38.3%) than the control group (55.1%). The 590A allele was significantly lower (p=0.033; OR=0.69, 95% CI: 0.49-0.79) in the patients (31.2%) compared with the controls (39.6%). Analysis of haplotypes showed that 481C, 803A, 590A, 587A combination was significantly different between the case and control women (p= 0.029; OR=3.11, 95% CI: 1.13-8.52).

Conclusion: The G590A SNP may be associated with susceptibility to endometriosis and the 590A allele may have a protective role in development of endometriosis. The 481C, 803A, 590A, 587A haplotype was associated with a higher risk of endometriosis in Iranian population.

Citing Articles

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Study on Genotyping Polymorphism and Sequencing of N-Acetyltransferase 2 (NAT2) among Al-Ahsa Population.

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NAT2 gene polymorphisms and endometriosis risk: A PRISMA-compliant meta-analysis.

Wei Z, Zhang M, Zhang X, Yi M, Xia X, Fang X PLoS One. 2019; 14(12):e0227043.

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Defining the genetic profile of endometriosis.

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Arylamine N-acetyltransferase 2 Polymorphisms and the Risk of Endometriosis.

Barra F, Desideri L, Scala C, Ferrero S Avicenna J Med Biotechnol. 2018; 10(4):277-278.

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