Symptom Perception, Placebo Effects, and the Bayesian Brain

Overview

Journal Pain

Specialties Neurology
Psychiatry

Date 2018 Aug 8

PMID 30086114

Citations 67

Authors

Giulio Ongaro

Ted J Kaptchuk

Affiliations

Soon will be listed here.

Citing Articles

Thermosensory predictive coding underpins an illusion of pain.

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Beyond Needling: Integrating a Bayesian Brain Model into Acupuncture Treatment.

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Healthcare-seeking behaviors and barriers among medical students in Egypt: a national cross-sectional study.

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A randomised, double-blind, placebo-controlled study to determine the analgesic efficacy, safety and tolerability of VPX638 administered topically to painful wounds.

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The complexity of caffeine's effects on regular coffee consumers.

Lesar M, Sajovic J, Novakovic D, Primozic M, Vetrih E, Sajovic M Heliyon. 2025; 11(2):e41471.

PMID: 39897922 PMC: 11786655. DOI: 10.1016/j.heliyon.2024.e41471.

References

Wechsler M, Kelley J, Boyd I, Dutile S, Marigowda G, Kirsch I . Active albuterol or placebo, sham acupuncture, or no intervention in asthma. N Engl J Med. 2011; 365(2):119-26. PMC: 3154208. DOI: 10.1056/NEJMoa1103319. View

Colagiuri B, Quinn V, Colloca L . Nocebo Hyperalgesia, Partial Reinforcement, and Extinction. J Pain. 2015; 16(10):995-1004. DOI: 10.1016/j.jpain.2015.06.012. View

Kam-Hansen S, Jakubowski M, Kelley J, Kirsch I, Hoaglin D, Kaptchuk T . Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci Transl Med. 2014; 6(218):218ra5. PMC: 4005597. DOI: 10.1126/scitranslmed.3006175. View

Carvalho C, Caetano J, Cunha L, Rebouta P, Kaptchuk T, Kirsch I . Open-label placebo treatment in chronic low back pain: a randomized controlled trial. Pain. 2016; 157(12):2766-2772. PMC: 5113234. DOI: 10.1097/j.pain.0000000000000700. View

Friston K, Shiner T, Fitzgerald T, Galea J, Adams R, Brown H . Dopamine, affordance and active inference. PLoS Comput Biol. 2012; 8(1):e1002327. PMC: 3252266. DOI: 10.1371/journal.pcbi.1002327. View

Wiech K . Deconstructing the sensation of pain: The influence of cognitive processes on pain perception. Science. 2016; 354(6312):584-587. DOI: 10.1126/science.aaf8934. View

Seth A, Suzuki K, Critchley H . An interoceptive predictive coding model of conscious presence. Front Psychol. 2012; 2:395. PMC: 3254200. DOI: 10.3389/fpsyg.2011.00395. View

Friston K . A theory of cortical responses. Philos Trans R Soc Lond B Biol Sci. 2005; 360(1456):815-36. PMC: 1569488. DOI: 10.1098/rstb.2005.1622. View

Wilkinson S . Accounting for the phenomenology and varieties of auditory verbal hallucination within a predictive processing framework. Conscious Cogn. 2014; 30:142-55. PMC: 5901710. DOI: 10.1016/j.concog.2014.09.002. View

10.

Kaptchuk T, Kelley J, Conboy L, Davis R, Kerr C, Jacobson E . Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. BMJ. 2008; 336(7651):999-1003. PMC: 2364862. DOI: 10.1136/bmj.39524.439618.25. View

11.

Barrett L, Simmons W . Interoceptive predictions in the brain. Nat Rev Neurosci. 2015; 16(7):419-29. PMC: 4731102. DOI: 10.1038/nrn3950. View

12.

Espay A, Norris M, Eliassen J, Dwivedi A, Smith M, Banks C . Placebo effect of medication cost in Parkinson disease: a randomized double-blind study. Neurology. 2015; 84(8):794-802. PMC: 4345649. DOI: 10.1212/WNL.0000000000001282. View

13.

Clark A . Whatever next? Predictive brains, situated agents, and the future of cognitive science. Behav Brain Sci. 2013; 36(3):181-204. DOI: 10.1017/S0140525X12000477. View

14.

Geuter S, Koban L, Wager T . The Cognitive Neuroscience of Placebo Effects: Concepts, Predictions, and Physiology. Annu Rev Neurosci. 2017; 40:167-188. DOI: 10.1146/annurev-neuro-072116-031132. View

15.

Brown H, Adams R, Parees I, Edwards M, Friston K . Active inference, sensory attenuation and illusions. Cogn Process. 2013; 14(4):411-27. PMC: 3824582. DOI: 10.1007/s10339-013-0571-3. View

16.

Benedetti F, Carlino E, Pollo A . Hidden administration of drugs. Clin Pharmacol Ther. 2011; 90(5):651-61. DOI: 10.1038/clpt.2011.206. View

17.

Jensen K, Kaptchuk T, Kirsch I, Raicek J, Lindstrom K, Berna C . Nonconscious activation of placebo and nocebo pain responses. Proc Natl Acad Sci U S A. 2012; 109(39):15959-64. PMC: 3465419. DOI: 10.1073/pnas.1202056109. View

18.

Gershman S . A Unifying Probabilistic View of Associative Learning. PLoS Comput Biol. 2015; 11(11):e1004567. PMC: 4633133. DOI: 10.1371/journal.pcbi.1004567. View

19.

Kaptchuk T . Open-Label Placebo: Reflections on a Research Agenda. Perspect Biol Med. 2018; 61(3):311-334. DOI: 10.1353/pbm.2018.0045. View

20.

Anchisi D, Zanon M . A Bayesian perspective on sensory and cognitive integration in pain perception and placebo analgesia. PLoS One. 2015; 10(2):e0117270. PMC: 4321992. DOI: 10.1371/journal.pone.0117270. View