Characteristic Inclusions in the Kidney of Canine Globoid Cell Leukodystrophy

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1986 Jan 1

PMID 3008490

Citations 1

Authors

K Suzuki

Affiliations

Soon will be listed here.

Abstract

The kidney of a 7-month-old male Cairn terrier with globoid cell leukodystrophy (GLD) was investigated with light and electron microscopes. A few tubular epithelial cells in the inner medulla as well as some exfoliated cells in the lumina revealed PAS-positive cytoplasm in which needle-like structures were to be seen on occasion. At the ultrastructural level, characteristic inclusions of GLD were found in these cells. This observation indicates that in addition to our previous report in the kidney of murine GLD (Takahashi et al. 1984), kidney in canine GLD also is a site of abnormal storage of galactosylceramide, although so far no morphological or biochemical evidence of galactosylceramide storage was demonstrated in human GLD.

Citing Articles

Eccrine gland involvement in Krabbe's disease.

Elleder M Virchows Arch A Pathol Anat Histopathol. 1992; 421(4):351-4.

PMID: 1413496 DOI: 10.1007/BF01660983.

References

FLETCHER T, Lee D, Hammer R . Ultrastructural features of globoid-cell leukodystrophy in the dog. Am J Vet Res. 1971; 32(1):177-81. View

Kobayashi T, Yamanaka T, Jacobs J, Teixeira F, Suzuki K . The Twitcher mouse: an enzymatically authentic model of human globoid cell leukodystrophy (Krabbe disease). Brain Res. 1980; 202(2):479-83. DOI: 10.1016/0006-8993(80)90159-6. View

Ida H, Umezawa F, Kasai E, Eto Y, Maekawa K . An accumulation of galactocerebroside in kidney from mouse globoid cell leukodystrophy (twitcher). Biochem Biophys Res Commun. 1982; 109(3):634-8. DOI: 10.1016/0006-291x(82)91987-8. View

Nilsson O, Svennerholm L . Characterization and quantitative determination of gangliosides and neutral glycosphingolipids in human liver. J Lipid Res. 1982; 23(2):327-34. View

Igisu H, Takahashi H, Suzuki K . Abnormal accumulation of galactosylceramide in the kidney of twitcher mouse. Biochem Biophys Res Commun. 1983; 110(3):940-4. DOI: 10.1016/0006-291x(83)91053-7. View

Yajima K, FLETCHER T, Suzuki K . Canine globoid cell leukodystrophy. Part 1. Further ultrastructural study of the typical lesion. J Neurol Sci. 1977; 33(1-2):179-97. DOI: 10.1016/0022-510x(77)90192-7. View

Suzuki K . Genetic galactosylceramidase deficiency (globoid cell leukodystrophy, Krabbe disease) in different mammalian species. Neurochem Pathol. 1985; 3(1):53-68. DOI: 10.1007/BF02834075. View

Makita A . BIOCHEMISTRY OF ORGAN GLYCOLIPIDS. II. ISOLATION OF HUMAN KIDNEY GLYCOLIPIDS. J Biochem. 1964; 55:269-76. DOI: 10.1093/oxfordjournals.jbchem.a127880. View

Andrews J, Cancilla P . Cytoplasmic inclusions in human globoid cell leukodystrophy. Krabbe's disease. Arch Pathol. 1970; 89(1):53-5. View

10.

MARTENSSON E . Neutral glycolipids of human kidney isolation, identification, and fatty acid composition. Biochim Biophys Acta. 1966; 116(2):296-308. DOI: 10.1016/0005-2760(66)90012-9. View

11.

Yunis E, Lee R . The morphologic similarities of human and canine globoid leukodystrophy. Thin section and freeze-fracture studies. Am J Pathol. 1976; 85(1):99-114. PMC: 2032546. View

12.

Pritchard D, Napthine D, Sinclair A . Globoid cell leucodystrophy in polled Dorset sheep. Vet Pathol. 1980; 17(4):399-405. DOI: 10.1177/030098588001700402. View

13.

Liu H . Ultrastructure of globoid leukodystrophy (Krabbe's disease) with reference to the origin of globoid cells. J Neuropathol Exp Neurol. 1970; 29(3):441-62. DOI: 10.1097/00005072-197007000-00008. View

14.

SCHOCHET Jr S, Hardman J, LAMPERT P, EARLE K . Krabbe's disease (globoid leukodystrophy). Electron microscopic observations. Arch Pathol. 1969; 88(3):305-13. View

15.

Bischoff A, Ulrich J . Peripheral neuropathy in globoid cell leukodystrophy (Krabbe's disease). Ultrastructural and histochemical findings. Brain. 1969; 92(4):861-70. DOI: 10.1093/brain/92.4.861. View

16.

Johnson K . Globoid leukodystrophy in the cat. J Am Vet Med Assoc. 1970; 157(12):2057-64. View

17.

FLETCHER T, Jessen C, Bender A . Quantitative evaluation of spinal cord lesions in canine globoid leukodystrophy. J Neuropathol Exp Neurol. 1977; 36(1):84-99. DOI: 10.1097/00005072-197701000-00009. View

18.

Okeda R, Suzuki Y, Horiguchi S, Fujii T . Fetal globoid cell leukodystrophy in one of twins. Acta Neuropathol. 1979; 47(2):151-4. DOI: 10.1007/BF00717039. View

19.

Zaki F, Kay W . Globoid cell leukodystrophy in a miniature poodle. J Am Vet Med Assoc. 1973; 163(3):248-50. View

20.

Anzil A, BLINZINGER K, Mehraein P, Dorn G, Neuhauser G . Cytoplasmic inclusions in a child affected with Krabbe's disease (globoid leucodystrophy) and in the rabbit injected with galactocerebrosides. J Neuropathol Exp Neurol. 1972; 31(2):370-88. DOI: 10.1097/00005072-197204000-00011. View