Non Plasmonic Semiconductor Quantum SERS Probe As a Pathway for in Vitro Cancer Detection

Overview

Journal Nat Commun

Specialty Biology

Date 2018 Aug 5

PMID 30076296

Citations 28

Authors

Rupa Haldavnekar

Krishnan Venkatakrishnan

Bo Tan

Affiliations

Soon will be listed here.

Abstract

Surface-enhanced Raman scattering (SERS)-based cancer diagnostics is an important analytical tool in early detection of cancer. Current work in SERS focuses on plasmonic nanomaterials that suffer from coagulation, selectivity, and adverse biocompatibility when used in vitro, limiting this research to stand-alone biomolecule sensing. Here we introduce a label-free, biocompatible, ZnO-based, 3D semiconductor quantum probe as a pathway for in vitro diagnosis of cancer. By reducing size of the probes to quantum scale, we observed a unique phenomenon of exponential increase in the SERS enhancement up to ~10 at nanomolar concentration. The quantum probes are decorated on a nano-dendrite platform functionalized for cell adhesion, proliferation, and label-free application. The quantum probes demonstrate discrimination of cancerous and non-cancerous cells along with biomolecular sensing of DNA, RNA, proteins and lipids in vitro. The limit of detection is up to a single-cell-level detection.

Citing Articles

Development and Biomedical Application of Non-Noble Metal Nanomaterials in SERS.

Chen L, Liu H, Gao J, Wang J, Jin Z, Lv M Nanomaterials (Basel). 2024; 14(20).

PMID: 39452990 PMC: 11510763. DOI: 10.3390/nano14201654.

Introduction and Development of Surface-Enhanced Raman Scattering (SERS) Substrates: A Review.

Peng J, Song Y, Lin Y, Huang Z Nanomaterials (Basel). 2024; 14(20).

PMID: 39452983 PMC: 11510290. DOI: 10.3390/nano14201648.

Development and Application of Surface-Enhanced Raman Scattering (SERS).

Huang Z, Peng J, Xu L, Liu P Nanomaterials (Basel). 2024; 14(17).

PMID: 39269079 PMC: 11397088. DOI: 10.3390/nano14171417.

Multiple valence states of Fe boosting SERS activity of FeO nanoparticles and enabling effective SERS-MRI bimodal cancer imaging.

Lin J, Ma X, Li A, Akakuru O, Pan C, He M Fundam Res. 2024; 4(4):858-867.

PMID: 39156566 PMC: 11330100. DOI: 10.1016/j.fmre.2022.04.018.

Paper/GO/e-Au flexible SERS sensors for detection of tricyclazole in orange juice and on cucumber skin at the sub-ppb level: machine learning-assisted data analysis.

Nguyen H, Mai Q, Nga D, Pham M, Nguyen Q, Do T Nanoscale Adv. 2024; 6(12):3106-3118.

PMID: 38868820 PMC: 11166118. DOI: 10.1039/d3na01113e.

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