Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion of and Their Biological Evaluations

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Aug 4

PMID 30071639

Citations 4

Authors

Jiwon Baek

Tae Kyoung Lee

Jae-Hyoung Song

Eunyong Choi

Hyun-Jeong Ko

Sanghyun Lee

Sang Un Choi

Seong Lee

Sang-Woo Yoo

Seon-Hee Kim

Ki Hyun Kim

Affiliations

Soon will be listed here.

Abstract

(Fabaceae), known as Chinese bushclover, has been used in traditional medicines for the treatment of diseases including diabetes, hematuria, and insomnia. As part of a continuing search for bioactive constituents from Korean medicinal plant sources, phytochemical analysis of the aerial portion of led to the isolation of two new lignan glycosides (,) along with three known lignan glycosides (⁻) and nine known flavonoid glycosides (⁻). Numerous analysis techniques, including 1D and 2D NMR spectroscopy, CD spectroscopy, HR-MS, and chemical reactions, were utilized for structural elucidation of the new compounds (,). The isolated compounds were evaluated for their applicability in medicinal use using cell-based assays. Compounds and ⁻ exhibited weak cytotoxicity against four human breast cancer cell lines (Bt549, MCF7, MDA-MB-231, and HCC70) (IC < 30.0 μM). However, none of the isolated compounds showed significant antiviral activity against PR8, HRV1B, or CVB3. In addition, compound produced fewer lipid droplets in Oil Red O staining of mouse mesenchymal stem cells compared to the untreated negative control without altering the amount of alkaline phosphatase staining.

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