» Articles » PMID: 30065853

Carney Complex: A Rare Case of Multicentric Cardiac Myxoma Associated with Endocrinopathy

Abstract

Carney complex is a rare autosomal dominant disorder characterized by multiple tumors, including cardiac and extracardiac myxomas, skin lesions, and various endocrine disorders. We are reporting a 21-year-old female patient with past surgical history significant for excision of a cutaneous myxoma who presented with multicentric cardiac myxomas involving the four cardiac chambers. She also presented with endocrinal disorders in the form of an enlarged right lobe of the thyroid, hyperthyroid state, and an incidentally noted adrenal cyst; hence, she was diagnosed with carney complex syndrome.

Citing Articles

Multimodality Cardiac Imaging Enhances Diagnosis and Management of Recurrent Atrial Myxomas in Carney Complex.

Patibandla S, Brito D, Sloyer D, Cook C, Badhwar V, Mills J CASE (Phila). 2021; 5(4):209-212.

PMID: 34430768 PMC: 8370850. DOI: 10.1016/j.case.2021.03.003.

References
1.
Kirschner L, Carney J, Pack S, Taymans S, Giatzakis C, Cho Y . Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Nat Genet. 2000; 26(1):89-92. DOI: 10.1038/79238. View

2.
Vidaillet Jr H, Seward J, Fyke 3rd F, Su W, Tajik A . "Syndrome myxoma": a subset of patients with cardiac myxoma associated with pigmented skin lesions and peripheral and endocrine neoplasms. Br Heart J. 1987; 57(3):247-55. PMC: 1216421. DOI: 10.1136/hrt.57.3.247. View

3.
Almeida M, Stratakis C . Carney complex and other conditions associated with micronodular adrenal hyperplasias. Best Pract Res Clin Endocrinol Metab. 2010; 24(6):907-14. PMC: 3000540. DOI: 10.1016/j.beem.2010.10.006. View

4.
Reynen K . Frequency of primary tumors of the heart. Am J Cardiol. 1996; 77(1):107. DOI: 10.1016/s0002-9149(97)89149-7. View

5.
Stratakis C, Kirschner L, Carney J . Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation. J Clin Endocrinol Metab. 2001; 86(9):4041-6. DOI: 10.1210/jcem.86.9.7903. View