Stereoselective Alkyne Hydrohalogenation by Trapping of Transfer Hydrogenation Intermediates

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2018 Aug 1

PMID 30062890

Citations 8

Authors

Manas Das

Trinadh Kaicharla

Johannes F Teichert

Affiliations

Soon will be listed here.

Abstract

A catalytically generated vinylcopper complex, the reactive intermediate of a copper(I)-catalyzed alkyne transfer hydrogenation, can be trapped by commercially available halogen electrophiles. In this manner, internal alkynes can stereoselectively be hydrohalogenated to the corresponding vinyl chlorides, bromides, and iodides.

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