LINC00675 is a Prognostic Factor and Regulates Cell Proliferation, Migration and Invasion in Glioma

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2018 Aug 1

PMID 30061182

Citations 7

Authors

Zhibing Li

Yijian Li

Qibai Wang

Affiliations

Soon will be listed here.

Abstract

LINC00675 has been suggested to be dysregulated in gastric cancer, colorectal cancer and pancreatic cancer. However, the expression status and biological function of LINC00675 in glioma were still unknown. Thus, we reported LINC00675 was overexpressed in glioma tissues and cell lines, and positively associated with advanced WHO grade, large tumor size and poor prognosis. Moreover, univariate and multivariate analyses suggested that high-expression of LINC00675 was an independent unfavorable prognostic predictor for glioma. In addition, levels of LINC00675 expression were positively correlated with TRIP6 mRNA and protein expressions. The experiment showed that silencing of LINC00675 inhibits glioma cell proliferation, migration and invasion through regulating TRIP6. In conclusion, LINC00675 acts as a tumor promoter in glioma progression.

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