Interleukin-5, Interleukin-6, Interferon Induced Protein-10, Procalcitonin and C-reactive Protein Among Mechanically Ventilated Severe Community-acquired Viral and Bacterial Pneumonia Patients

Overview

Journal Cytokine

Specialties Allergy & Immunology
Biology

Date 2018 Jul 30

PMID 30055898

Citations 10

Authors

Jaana Karhu

Tero Ilmari Ala-Kokko

Tytti Vuorinen

Pasi Ohtonen

Ilkka Julkunen

Hannu Tapani Syrjala

Affiliations

Soon will be listed here.

Abstract

Background: The serum cytokine levels among 45 mechanically ventilated, intensive care unit (ICU)-treated severe community-acquired pneumonia (SCAP) patients with known microbial etiology in three different etiology groups were assessed.

Methods: Blood samples for C-reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-5, IL-6, IL-10, human interferon gamma induced protein (IP)-10, and TNF-α (tumor necrosis factor alpha) were collected at time points 0, 12, 24, 48, 72 and 96 h after study inclusion.

Results: There were 21 (43%) pure bacterial infections (bacterial group, BG), 5 (10%) pure viral infections (viral group, VG), and 19 (39%) mixed bacterial-viral infections (mixed group, MG) among 45 mechanically ventilated SCAP patients. CRP and PCT levels were significantly higher in the MG and values decreased with time in all groups. PCT differed also in time and group analysis (P = 0.001), the highest being in the MG. IL-5 levels were significantly higher in the VG compared to others (P = 0.001, P = 0.051 and P = 0.016). IL-6 and IP-10 levels decreased over time (P = 0.003 and P = 0.021), but there were no differences between groups.

Conclusion: SCAP patients with viral etiology have higher IL-5 levels. Patients with mixed viral and bacterial group have higher PCT compared to other etiologies.

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