Effects of Antimicrobial Therapy on Faecal Bulking

Overview

Journal Gut

Specialty Gastroenterology

Date 1986 Jan 1

PMID 3005139

Citations 5

Authors

A V Kurpad

P S Shetty

Affiliations

Soon will be listed here.

Abstract

It has recently been postulated that dietary fibre acts as a substrate for colonic flora, and that the resultant microbial growth bulks the faeces. Antimicrobial therapy was used in this study to assess the effect of reduction in colonic microbial proliferation on faecal output in human subjects on a constant dietary fibre intake. Six healthy young male subjects were maintained on constant daily diets and metronidazole (1 g/day) and ampicillin (1 g/day) were administered in divided doses for one week after an initial baseline study period of two weeks. After antimicrobial therapy, mean faecal weights rose from 176.0 +/- 27.0 g to 348.1 +/- 37.7 g/day. Faecal solids increased from 32.9 +/- 4.2 g to 46.1 +/- 5.8 g/day. Faecal neutral detergent fibre increased from 1.92 +/- 0.42 g to 15.19 +/- 2.58 g/day. The mean transit times and mean daily faecal nitrogen remained the same, both before and after treatment. Substantial breakdown of dietary fibre occurs in the human colon which may decrease faecal bulk, suggesting that water holding by dietary fibre is probably of greater importance for faecal bulking.

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References

Burkitt D, Walker A, Painter N . Effect of dietary fibre on stools and the transit-times, and its role in the causation of disease. Lancet. 1972; 2(7792):1408-12. DOI: 10.1016/s0140-6736(72)92974-1. View

Shetty P, Kurpad A . Intestinal transit time of south Indian subjects. Indian J Med Res. 1984; 80:693-8. View

Goldring J, MCNAUGHT W, Scott A, Gillespie G . Prophylactic oral antimicrobial agents in elective colonic surgery. A controlled trial. Lancet. 1975; 2(7943):997-1000. DOI: 10.1016/s0140-6736(75)90289-5. View

Eastwood M . The role of vegetable dietary fibre in human nutrition. Med Hypotheses. 1975; 1(2):46-53. DOI: 10.1016/s0306-9877(75)80015-6. View

Cummings J, Jenkins D, Wiggins H . Measurement of the mean transit time of dietary residue through the human gut. Gut. 1976; 17(3):210-8. PMC: 1411154. DOI: 10.1136/gut.17.3.210. View

Cummings J, Hill M, Jenkins D, PEARSON J, Wiggins H . Changes in fecal composition and colonic function due to cereal fiber. Am J Clin Nutr. 1976; 29(12):1468-73. DOI: 10.1093/ajcn/29.12.1468. View

SOUTHGATE D, Bailey B, COLLINSON E, Walker A . A guide to calculating intakes of dietary fibre. J Hum Nutr. 1976; 30(5):303-13. DOI: 10.3109/09637487609144013. View

Weber Jr F . The effect of lactulose on urea metabolism and nitrogen excretion in cirrhotic patients. Gastroenterology. 1979; 77(3):518-23. View

Cummings J, SOUTHGATE D, Branch W, Wiggins H, Houston H, Jenkins D . The digestion of pectin in the human gut and its effect on calcium absorption and large bowel function. Br J Nutr. 1979; 41(3):477-85. DOI: 10.1079/bjn19790062. View

10.

Stephen A, Cummings J . Water-holding by dietary fibre in vitro and its relationship to faecal output in man. Gut. 1979; 20(8):722-9. PMC: 1412537. DOI: 10.1136/gut.20.8.722. View

11.

Stephen A, Cummings J . The microbial contribution to human faecal mass. J Med Microbiol. 1980; 13(1):45-56. DOI: 10.1099/00222615-13-1-45. View

12.

Stephen A, Cummings J . Mechanism of action of dietary fibre in the human colon. Nature. 1980; 284(5753):283-4. DOI: 10.1038/284283a0. View

13.

Weber Jr F, Fresard K . Comparative effects of lactulose and magnesium sulfate on urea metabolism and nitrogen excretion in cirrhotic subjects. Gastroenterology. 1981; 80(5 pt 1):994-8. View

14.

Cummings J . Short chain fatty acids in the human colon. Gut. 1981; 22(9):763-79. PMC: 1419865. DOI: 10.1136/gut.22.9.763. View

15.

Wharton P, Eaton P, Day K . Sorrento Asian food tables: food tables, recipes and customs of mothers attending Sorrento Maternity Hospital, Birmingham, England. Hum Nutr Appl Nutr. 1983; 37(5):378-402. View

16.

Cummings J . Microbial digestion of complex carbohydrates in man. Proc Nutr Soc. 1984; 43(1):35-44. DOI: 10.1079/pns19840025. View

17.

Tally F, Sutter V, Finegold S . Treatment of anaerobic infections with metronidazole. Antimicrob Agents Chemother. 1975; 7(5):672-5. PMC: 429201. DOI: 10.1128/AAC.7.5.672. View