The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) Clinical Biomarker: Study Design and Protocol

Overview

Journal Neurobiol Dis

Specialty Neurology

Date 2018 Jul 27

PMID 30048805

Citations 20

Authors

Paul M Vespa

Vikesh Shrestha

Nicholas Abend

Denes Agoston

Alicia Au

Michael J Bell

Thomas P Bleck

Manuel Buitrago Blanco

Jan Claassen

Ramon Diaz-Arrastia

Dominique Duncan

Ben Ellingson

Brandon Foreman

Emily J Gilmore

Lawrence Hirsch

Martin Hunn

Alaa Kamnaksh

David McArthur

Andrew Morokoff

Terrence OBrien

Kristine OPhelan

Courtney L Robertson

Eric Rosenthal

Richard Staba

Arthur Toga

Frederick A Willyerd

Lara Zimmermann

Elisa Yam

Susana Martinez

Courtney Real

Jerome Engel Jr

Affiliations

Soon will be listed here.

Abstract

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.

Citing Articles

Changes in Hippocampal Volume after Traumatic Brain Injury (TBI).

Kriukova K, Boswell M, Asifriyaz T, Gong J, Duncan D, Vespa P Res Sq. 2024; .

PMID: 39678337 PMC: 11643318. DOI: 10.21203/rs.3.rs-5390622/v1.

Preclinical Testing Strategies for Epilepsy Therapy Development.

Riley V, Danzer S Epilepsy Curr. 2024; :15357597241292197.

PMID: 39539399 PMC: 11556302. DOI: 10.1177/15357597241292197.

Insights into epileptogenesis from post-traumatic epilepsy.

Pease M, Gupta K, Moshe S, Correa D, Galanopoulou A, Okonkwo D Nat Rev Neurol. 2024; 20(5):298-312.

PMID: 38570704 DOI: 10.1038/s41582-024-00954-y.

Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies.

Bhagavatula S, Cabeen R, Harris N, Grohn O, Wright D, Garner R Epilepsy Res. 2023; 195:107201.

PMID: 37562146 PMC: 10528111. DOI: 10.1016/j.eplepsyres.2023.107201.

Manual lesion segmentations for traumatic brain injury characterization.

Bennett A, Garner R, Morris M, La Rocca M, Barisano G, Cua R Front Neuroimaging. 2023; 2:1068591.

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