The Yin-yang of the Interaction Between Myelomonocytic Cells and NK Cells

Overview

Journal Scand J Immunol

Specialty Allergy & Immunology

Date 2018 Jul 27

PMID 30048003

Citations 26

Authors

Martina Molgora

Domenico Supino

Domenico Mavilio

Angela Santoni

Lorenzo Moretta

Alberto Mantovani

Cecilia Garlanda

Affiliations

Soon will be listed here.

Abstract

NK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular, macrophages, dendritic cells and neutrophils promote differentiation and effector function of NK cells and, on the other hand, myelomonocytic cells express triggers of checkpoint blockade (eg PD-L1) and other immunosuppressive molecules, which negatively regulate NK cell function. In addition, NK cells express high levels of IL-1R8, which acts as a checkpoint for IL-18 driven differentiation and activation of NK cells. Evidence suggests that targeting the myeloid cell-NK cell crosstalk unleashes effective anti-tumour and anti-viral resistance.

Citing Articles

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