Prevalence of Gene Among Extended-Spectrum β-Lactamases Producing Clinical Isolates in Iran: A Meta-Analysis

Overview

Journal Iran J Med Sci

Publisher Shiraz University of Medical Sciences

Specialty General Medicine

Date 2018 Jul 27

PMID 30046202

Citations 5

Authors

Ebrahim Eskandari-Nasab MSc

Mehdi Moghadampour MSc

Arezoo Tahmasebi MSc

Affiliations

Soon will be listed here.

Abstract

Background: CTX-M-type extended-spectrum β-lactamases (ESBLs) are the most prevalent ESBLs in bacterial members of Enterobacteriaceae family including . The global spread of CTX-M-producing is a major concern in most countries including Iran. The aim of this meta-analysis was to determine the relative frequency (RF) of gene among ESBLs-producing clinical isolates in Iran and to report an overall prevalence.

Methods: A comprehensive literature search of studies published up to July 2016 was carried out. The keywords "Enterobacteriaceae", "", "ESBLs", "CTX-M" and "Iran" were searched in PubMed, Scopus, EBSCO, Google Scholar, Scirus, SID and IranMedex in both English and Persian. Selected articles were published between July 2010 and July 2016 and all of them were in English. STATA SE version 11.0 was used for statistical analysis.

Results: Twenty-four articles/abstracts were included in this analysis. Selected studies were performed in Ahvaz, Arak, Ilam, Kashan, Kerman, Mashhad, Shiraz, Tabriz, Tehran, Zabol, and Zahedan. Our pooled evidence showed that the RF of blaCTX-M gene among ESBLs-producing clinical isolates varied from 7.7% in Tabriz to 100% in Mashhad, Tehran, and Zahedan, with an overall RF of 56.7%.

Conclusion: Our meta-analysis revealed that the RF of CTX-M-type ESBLs-producing is diverse in different regions of Iran, and the central and eastern regions had higher prevalence rates compared to western regions.

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