The Different Routes to Metastasis Via Hypoxia-Regulated Programs

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2018 Jul 26

PMID 30041830

Citations 60

Authors

Ana Rita Nobre

David Entenberg

Yarong Wang

John Condeelis

Julio A Aguirre-Ghiso

Affiliations

Soon will be listed here.

Abstract

Hypoxia is linked to metastasis; however, how it affects metastatic progression is not clear due to limited consensus in the literature. We posit that this lack of consensus is due to hypoxia being studied using different approaches, such as in vitro, primary tumor, or metastasis assays in an isolated manner. Here, we review the pros and cons of in vitro hypoxia assays, highlight in vivo studies that inform on physiological hypoxia, and review the evidence that primary tumor hypoxia might influence the fate of disseminated tumor cells (DTCs) in secondary organs. Our analysis suggests that consensus can be reached by using in vivo methods of study, which also allow better modeling of how hypoxia affects DTC fate and metastasis.

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