Integrated Histotripsy and Bubble Coalescence Transducer for Rapid Tissue Ablation

Overview

Journal IEEE Trans Ultrason Ferroelectr Freq Control

Specialties Biomedical Engineering
Nuclear Medicine

Date 2018 Jul 25

PMID 30040636

Citations 9

Authors

Aiwei Shi

Zhen Xu

Jonathan Lundt

Hedieh A Tamaddoni

Tejaswi Worlikar

Timothy L Hall

Affiliations

Soon will be listed here.

Abstract

Residual bubbles produced after collapse of a cavitation cloud provide cavitation nuclei for subsequent cavitation events, causing cavitation to occur repeatedly at the same discrete set of sites. This effect, referred to as cavitation memory, limits the efficiency of histotripsy soft tissue fractionation. Besides passively mitigating cavitation memory by using a low pulse repetition frequency (~1 Hz), an active strategy was developed by our group. In this strategy, low-amplitude ultrasound sequences were used to stimulate coalescence of residual bubbles. The goal of this work is to remove cavitation memory and achieve rapid, homogeneous lesion formation using a single phased array transducer. A 1-MHz integrated histotripsy and bubble coalescing (BC) transducer system with a specialized electronic driving system was built in house. High-amplitude ( MPa) histotripsy pulses and subsequent low-amplitude (~1-2 MPa) BC sequences were applied to a red blood cell tissue-mimicking phantom at a single focal site. Significant reduction of the cavitation memory effect and increase in the fractionation rate were observed by introducing BC sequence. Effects of BC pulsing parameters were further studied. The optimal BC parameters were then utilized to homogenize a mm region at high rate.

Citing Articles

Insights from preclinical cancer studies with histotripsy.

Worlikar T, Hall T, Zhang M, Mendiratta-Lala M, Green M, Cho C Int J Hyperthermia. 2024; 41(1):2297650.

PMID: 38214171 PMC: 11102041. DOI: 10.1080/02656736.2023.2297650.

The histotripsy spectrum: differences and similarities in techniques and instrumentation.

Williams R, Simon J, Khokhlova V, Sapozhnikov O, Khokhlova T Int J Hyperthermia. 2023; 40(1):2233720.

PMID: 37460101 PMC: 10479943. DOI: 10.1080/02656736.2023.2233720.

Histotripsy Bubble Cloud Contrast With Chirp-Coded Excitation in Preclinical Models.

Wallach E, Shekhar H, Flores-Guzman F, Hernandez S, Bader K IEEE Trans Ultrason Ferroelectr Freq Control. 2021; 69(2):787-794.

PMID: 34748487 PMC: 11652668. DOI: 10.1109/TUFFC.2021.3125922.

Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging.

Bader K, Wallach E, Shekhar H, Flores-Guzman F, Halpern H, Hernandez S Phys Med Biol. 2021; 66(16).

PMID: 34271560 PMC: 10680990. DOI: 10.1088/1361-6560/ac155d.

Scan Parameter Optimization for Histotripsy Treatment of S. Aureus Biofilms on Surgical Mesh.

Bigelow T, Thomas C, Wu H IEEE Trans Ultrason Ferroelectr Freq Control. 2019; 67(2):341-349.

PMID: 31634828 PMC: 7039400. DOI: 10.1109/TUFFC.2019.2948305.

References

Zeng X, McGough R . Evaluation of the angular spectrum approach for simulations of near-field pressures. J Acoust Soc Am. 2008; 123(1):68-76. PMC: 3408224. DOI: 10.1121/1.2812579. View

Lundt J, Allen S, Shi J, Hall T, Cain C, Xu Z . Non-invasive, Rapid Ablation of Tissue Volume Using Histotripsy. Ultrasound Med Biol. 2017; 43(12):2834-2847. PMC: 5693635. DOI: 10.1016/j.ultrasmedbio.2017.08.006. View

Alles E, Zhu Y, van Dongen K, McGough R . Rapid transient pressure field computations in the nearfield of circular transducers using frequency-domain time-space decomposition. Ultrason Imaging. 2012; 34(4):237-60. PMC: 3835603. DOI: 10.1177/0161734612463847. View

Maxwell A, Wang T, Yuan L, Duryea A, Xu Z, Cain C . A tissue phantom for visualization and measurement of ultrasound-induced cavitation damage. Ultrasound Med Biol. 2010; 36(12):2132-43. PMC: 2997329. DOI: 10.1016/j.ultrasmedbio.2010.08.023. View

Xu Z, Owens G, Gordon D, Cain C, Ludomirsky A . Noninvasive creation of an atrial septal defect by histotripsy in a canine model. Circulation. 2010; 121(6):742-9. PMC: 2834201. DOI: 10.1161/CIRCULATIONAHA.109.889071. View

Xu J, Bigelow T, Riesberg G . Impact of preconditioning pulse on lesion formation during high-intensity focused ultrasound histotripsy. Ultrasound Med Biol. 2012; 38(11):1918-29. DOI: 10.1016/j.ultrasmedbio.2012.06.009. View

Vlaisavljevich E, Kim Y, Allen S, Owens G, Pelletier S, Cain C . Image-guided non-invasive ultrasound liver ablation using histotripsy: feasibility study in an in vivo porcine model. Ultrasound Med Biol. 2013; 39(8):1398-409. PMC: 3709011. DOI: 10.1016/j.ultrasmedbio.2013.02.005. View

Huber P, Debus J, Jochle K, Simiantonakis I, Jenne J, Rastert R . Control of cavitation activity by different shockwave pulsing regimes. Phys Med Biol. 1999; 44(6):1427-37. DOI: 10.1088/0031-9155/44/6/301. View

Wang T, Xu Z, Hall T, Fowlkes J, Cain C . An efficient treatment strategy for histotripsy by removing cavitation memory. Ultrasound Med Biol. 2012; 38(5):753-66. PMC: 3462164. DOI: 10.1016/j.ultrasmedbio.2012.01.013. View

10.

Roberts W, Hall T, Ives K, Wolf Jr J, Fowlkes J, Cain C . Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney. J Urol. 2006; 175(2):734-8. DOI: 10.1016/S0022-5347(05)00141-2. View

11.

Hall T, Hempel C, Wojno K, Xu Z, Cain C, Roberts W . Histotripsy of the prostate: dose effects in a chronic canine model. Urology. 2009; 74(4):932-7. PMC: 2757508. DOI: 10.1016/j.urology.2009.03.049. View

12.

Maxwell A, Owens G, Gurm H, Ives K, Myers Jr D, Xu Z . Noninvasive treatment of deep venous thrombosis using pulsed ultrasound cavitation therapy (histotripsy) in a porcine model. J Vasc Interv Radiol. 2011; 22(3):369-77. PMC: 3053086. DOI: 10.1016/j.jvir.2010.10.007. View

13.

Owens G, Miller R, Ensing G, Ives K, Gordon D, Ludomirsky A . Therapeutic ultrasound to noninvasively create intracardiac communications in an intact animal model. Catheter Cardiovasc Interv. 2010; 77(4):580-8. PMC: 3010446. DOI: 10.1002/ccd.22787. View

14.

Parsons J, Cain C, Abrams G, Fowlkes J . Pulsed cavitational ultrasound therapy for controlled tissue homogenization. Ultrasound Med Biol. 2005; 32(1):115-29. DOI: 10.1016/j.ultrasmedbio.2005.09.005. View

15.

Devanagondi R, Zhang X, Xu Z, Ives K, Levin A, Gurm H . Hemodynamic and Hematologic Effects of Histotripsy of Free-Flowing Blood: Implications for Ultrasound-Mediated Thrombolysis. J Vasc Interv Radiol. 2015; 26(10):1559-65. PMC: 4584157. DOI: 10.1016/j.jvir.2015.03.022. View

16.

Hall T, Kieran K, Ives K, Fowlkes J, Cain C, Roberts W . Histotripsy of rabbit renal tissue in vivo: temporal histologic trends. J Endourol. 2007; 21(10):1159-66. DOI: 10.1089/end.2007.9915. View

17.

Parsons J, Cain C, Fowlkes J . Cost-effective assembly of a basic fiber-optic hydrophone for measurement of high-amplitude therapeutic ultrasound fields. J Acoust Soc Am. 2006; 119(3):1432-40. DOI: 10.1121/1.2166708. View

18.

Xu Z, Fowlkes J, Ludomirsky A, Cain C . Investigation of intensity thresholds for ultrasound tissue erosion. Ultrasound Med Biol. 2005; 31(12):1673-82. PMC: 2676879. DOI: 10.1016/j.ultrasmedbio.2005.07.016. View

19.

Khokhlova V, Fowlkes J, Roberts W, Schade G, Xu Z, Khokhlova T . Histotripsy methods in mechanical disintegration of tissue: towards clinical applications. Int J Hyperthermia. 2015; 31(2):145-62. PMC: 4448968. DOI: 10.3109/02656736.2015.1007538. View

20.

Duryea A, Tamaddoni H, Cain C, Roberts W, Hall T . Removal of residual nuclei following a cavitation event: a parametric study. IEEE Trans Ultrason Ferroelectr Freq Control. 2016; 62(9):1605-14. PMC: 4698903. DOI: 10.1109/TUFFC.2014.006601. View