The Gut Microbiome and Irritable Bowel Syndrome

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2018 Jul 21

PMID 30026921

Citations 57

Authors

Stacy Menees

William Chey

Affiliations

Soon will be listed here.

Abstract

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders encountered in clinical practice. It is a heterogeneous disorder with a multifactorial pathogenesis. Recent studies have demonstrated that an imbalance in gut bacterial communities, or "dysbiosis", may be a contributor to the pathophysiology of IBS. There is evidence to suggest that gut dysbiosis may lead to activation of the gut immune system with downstream effects on a variety of other factors of potential relevance to the pathophysiology of IBS. This review will highlight the data addressing the emerging role of the gut microbiome in the pathogenesis of IBS and review the evidence for current and future microbiome based treatments.

Citing Articles

Navigating the Microbial Landscape: Understanding Dysbiosis in Human Genital Tracts and Its Impact on Fertility.

Ughade P, Shrivastava D, Chaudhari K Cureus. 2024; 16(8):e67040.

PMID: 39286717 PMC: 11403153. DOI: 10.7759/cureus.67040.

Cross-Cohort Gut Microbiome Signatures of Irritable Bowel Syndrome Presentation and Treatment.

Li J, Ghosh T, Arendt E, Shanahan F, OToole P Adv Sci (Weinh). 2024; 11(41):e2308313.

PMID: 39243395 PMC: 11538712. DOI: 10.1002/advs.202308313.

The role of gut microbiota augmentation in managing non-alcoholic fatty liver disease: an in-depth umbrella review of meta-analyses with grade assessment.

Maddineni G, Obulareddy S, Paladiya R, Korsapati R, Jain S, Jeanty H Ann Med Surg (Lond). 2024; 86(8):4714-4731.

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Vaginal and rectal microbiome contribute to genital inflammation in chronic pelvic pain.

Jimenez N, Norton T, Diadala G, Bell E, Valenti M, Farland L BMC Med. 2024; 22(1):283.

PMID: 38972981 PMC: 11229265. DOI: 10.1186/s12916-024-03500-1.

A meta-analysis of randomized controlled trials evaluating the effectiveness of fecal microbiota transplantation for patients with irritable bowel syndrome.

Wang Y, Hu Y, Shi P BMC Gastroenterol. 2024; 24(1):217.

PMID: 38970007 PMC: 11225114. DOI: 10.1186/s12876-024-03311-x.

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