Comparison of the Clinical Outcome of Frozen-thawed Embryo Transfer with and Without Pretreatment with a Gonadotropin-releasing Hormone Agonist

Overview

Journal Obstet Gynecol Sci

Specialty Gynecology & Obstetrics

Date 2018 Jul 19

PMID 30018903

Citations 8

Authors

Jieun Kang

Jisun Park

Dawn Chung

San Hui Lee

Eun Young Park

Kyung-Hee Han

Seoung Jin Choi

In-Bai Chung

Hyuck Dong Han

Yeon Soo Jung

Affiliations

Soon will be listed here.

Abstract

Objective: To describe the clinical outcomes of frozen-thawed embryo transfer (FET) with artificial preparation of the endometrium, using a combination of estrogen (E2) and progesterone (P4) with or without a gonadotropin-releasing hormone agonist (GnRHa), and the modified natural cycle (MNC) with human chorionic gonadotropin (hCG) trigger.

Methods: In this retrospective study, we evaluated 187 patients during 3 years (February 2012-April 2015). The patients were allocated to the following treatment groups: group A, comprising 113 patients (181 cycles) who received GnRHa+E2+P4; group B, comprising 49 patients (88 cycles) who received E2+P4; and group C, comprising 25 patients (42 cycles) who received hCG+P4. The inclusion criteria were regular menstrual cycles (length 24-35 days) and age 21-45 years.

Results: The primary outcome of the study - implantation rate (IR) per embryo transferred - was not statistically different among the 3 groups. Similar results were found for the IRs with fetal heartbeat per embryo transferred (68/181 [37.6%] in group A vs. 22/88 [25.0%] in group B vs. 14/42 [33.3%] in group C) and for the live birth rates (LBRs) per embryo transferred (56/181 [30.9%] in group A vs. 18/88 [20.5%] in group B vs. 11/42 [26.2%] in group C).

Conclusion: Although the pregnancy outcomes were better in the hormone therapy with GnRHa group, hormone therapy FET with GnRHa for pituitary suppression did not result in significantly improved IRs and LBRs when compared with hormone therapy FET without GnRHa or MNC FET.

Citing Articles

Effect of GnRH agonist down-regulation combined with hormone replacement treatment on reproductive outcomes of frozen blastocyst transfer cycles in women of different ages.

Xie J, Lu J, Zhang H PeerJ. 2024; 12:e17447.

PMID: 38832029 PMC: 11146325. DOI: 10.7717/peerj.17447.

Pituitary Suppression with Gonadotropin-Releasing Hormone Agonist Prior to Artificial Endometrial Preparation in Frozen-Thawed Embryo Transfer Cycles: A Systematic Review and Meta-Analysis of Different Protocols and Infertile Populations.

Ho N, Ho D, Tomai X, Nguyen N, Nguyen H, Hu Y Biomedicines. 2024; 12(4).

PMID: 38672116 PMC: 11048410. DOI: 10.3390/biomedicines12040760.

Comparison between oral dydrogesterone versus micronized vaginal progesterone gel in clinical outcome within the first HRT-FET cycle: a retrospective analysis.

Ye T, Luo L, Huang Y, Ding S Arch Gynecol Obstet. 2024; 309(5):2167-2173.

PMID: 38503849 DOI: 10.1007/s00404-024-07465-7.

Pretreatment with a long-acting GnRH agonist for frozen-thawed embryo transfer cycles: how to improve live birth?.

Xu B, Hou Z, Liu N, Zhao J, Li Y J Ovarian Res. 2023; 16(1):197.

PMID: 37743479 PMC: 10518919. DOI: 10.1186/s13048-023-01277-0.

Slightly Elevated Progesterone on HCG Trigger Day Has an Impact on Pregnancy Outcomes of Fresh Single Blastocyst Transfer Cycles Under an Early Follicular Phase Prolonged Protocol Cycle.

Wei L, Zhao Y, Xu C, Zhang C Int J Womens Health. 2022; 14:1761-1768.

PMID: 36568124 PMC: 9784381. DOI: 10.2147/IJWH.S385362.

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