PARP1-Erk Synergism in Proliferating Cells

Overview

Journal Oncotarget

Specialty Oncology

Date 2018 Jul 19

PMID 30018741

Citations 7

Authors

Leonid Visochek

Malka Cohen-Armon

Affiliations

Soon will be listed here.

Abstract

A synergism between PARP1 and phosphorylated Erk mediating IEG (immediate early gene) expression has been recently reported in cerebral neurons and cardiomyocytes. Stimulation induced PARP-Erk synergism was required for IEG expression underlying synaptic plasticity and long-term memory acquisition during learning. It was similarly required for cardiomyocytes development. Here, we identified this mechanism in Erk-induced gene expression promoting proliferation. This mechanism can be targeted in malignant cells.

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