Targeted Metabolomic Approach in Men with Carotid Plaque

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Jul 17

PMID 30011297

Citations 6

Authors

Teresa Auguet

Gemma Aragones

Marina Colom

Carmen Aguilar

Vicente Martin-Paredero

Nuria Canela

Xavier Ruyra

Cristobal Richart

Affiliations

Soon will be listed here.

Abstract

Background: The aim of the study was to analyse the presence of several metabolites related to atherosclerosis in the plasma of patients with unstable carotid plaque and in the plasma of healthy subjects.

Materials And Methods: We included 20 patients who had undergone carotid endarterectomy and 20 healthy subjects as a control group. All the subjects recruited were male. We used a metabolomic approach with liquid chromatography coupled to mass spectrometry to evaluate plasma metabolite levels in the metabolic pathway involved in the progression of atherosclerotic plaque.

Results: We observed that circulating levels of 20-HETE were significantly higher in patients with atheroma plaque than in healthy subjects (p = 0.018). No differences were found with regard to the other metabolites analysed. We also conducted a random forest analysis and found that 20-HETE was the main differentiator in the list of selected metabolites. In addition, plasma levels of 20-HETE correlated positively with body mass index (r = 0.427, p = 0.007) and diastolic blood pressure (r = 0.365, p = 0.028).

Conclusion: This study confirms that of all the molecules studied only 20-HETE is related to carotid plaque. Further studies are needed to compare patients with stable carotid plaque vs. patients with unstable carotid plaque in order to confirm that 20-HETE could be a potential factor related to carotid plaque.

Citing Articles

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Conflicting Roles of 20-HETE in Hypertension and Stroke.

Shekhar S, Varghese K, Li M, Fan L, Booz G, Roman R Int J Mol Sci. 2019; 20(18).

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