Advanced Oxidation Protein Products and Serum Total Oxidant/antioxidant Status Levels in Rosacea

Overview

Journal Postepy Dermatol Alergol

Publisher Termedia

Specialty Allergy & Immunology

Date 2018 Jul 17

PMID 30008650

Citations 11

Authors

Hilal Kaya Erdogan

Isil Bulur

Evin Kocaturk

Zeynep Nurhan Saracoglu

Ozkan Alatas

Muzaffer Bilgin

Affiliations

Soon will be listed here.

Abstract

Introduction: Rosacea is a chronic, inflammatory dermatosis which develops due to the effect of genetic and environmental factors.

Aim: To evaluate the oxidative stress in rosacea patients by measuring serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and advanced oxidation protein products (AOPP) levels in our study.

Material And Methods: Our study included rosacea patients and healthy volunteers aged between 18 and 65 years. Total antioxidant status, TOS and AOPP levels were measured and OSI was calculated.

Results: The study included 70 rosacea patients and 30 healthy volunteers as a control group. When TAS, TOS, OSI and AOPP levels were compared between rosacea and control groups, there was no difference for OSI levels; while TAS, TOS and AOPP levels were significantly higher in the rosacea group ( = 0.151, = 0.013, = 0.034, = 0.017, respectively). In the rosacea group, there was no correlation between TAS, TOS, OSI and AOPP levels and disease duration. Besides there was no difference between family history, rosacea type, symptom frequency and ocular involvement and TAS, TOS, OSI and AOPP levels in the rosacea group.

Conclusions: We observed that serum TAS, TOS and AOPP levels were significantly higher in rosacea patients, but there was no significant difference among the disease activity parameters. These results can support the role of oxidative stress in the pathogenesis of rosacea.

Citing Articles

Oxidative stress mediated by the NOX2/ROS/NF-κB signaling axis is involved in rosacea.

Wang Y, Long L, Chen M, Li J Arch Dermatol Res. 2025; 317(1):505.

PMID: 40014137 DOI: 10.1007/s00403-025-03898-5.

Investigation of Thiol/Disulfide Homeostasis and Clinical Parameters in Rosacea Patients According to Skin Subtypes.

Yesilirmak N, Saritas O, Kurt B, Neselioglu S, Aktas A, Erel O J Clin Med. 2024; 13(14).

PMID: 39064093 PMC: 11277807. DOI: 10.3390/jcm13144052.

Rosacea in Older Adults and Pharmacologic Treatments.

Lee J, Chien A Drugs Aging. 2024; 41(5):407-421.

PMID: 38649625 DOI: 10.1007/s40266-024-01115-y.

Evaluation of Ocular and Systemic Oxidative Stress Markers in Ocular Rosacea Patients.

Yesilirmak N, Bukan N, Kurt B, Yuzbasioglu S, Zhao M, Rodrigues-Braz D Invest Ophthalmol Vis Sci. 2023; 64(13):22.

PMID: 37843493 PMC: 10584021. DOI: 10.1167/iovs.64.13.22.

Increased Risk of Glaucoma in Patients with Rosacea: A Nationwide Population-Based Cohort Study.

Chae K, Kim S, Kim S, Woo Y J Clin Med. 2023; 12(11).

PMID: 37297954 PMC: 10253517. DOI: 10.3390/jcm12113759.

References

Yazici C, Kose K, Calis M, Demir M, Kirnap M, Ates F . Increased advanced oxidation protein products in Behçet's disease: a new activity marker?. Br J Dermatol. 2004; 151(1):105-11. DOI: 10.1111/j.1365-2133.2004.06003.x. View

Erel O . A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004; 37(4):277-85. DOI: 10.1016/j.clinbiochem.2003.11.015. View

Erel O . A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005; 38(12):1103-11. DOI: 10.1016/j.clinbiochem.2005.08.008. View

Witko-Sarsat V, Friedlander M, Nguyen-Khoa T, Nguyen A, Zingraff J, Jungers P . Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int. 1996; 49(5):1304-13. DOI: 10.1038/ki.1996.186. View

Bakar O, Demircay Z, Yuksel M, Haklar G, Sanisoglu Y . The effect of azithromycin on reactive oxygen species in rosacea. Clin Exp Dermatol. 2007; 32(2):197-200. DOI: 10.1111/j.1365-2230.2006.02322.x. View

Takci Z, Bilgili S, Karadag A, Kucukoglu M, Selek S, Aslan M . Decreased serum paraoxonase and arylesterase activities in patients with rosacea. J Eur Acad Dermatol Venereol. 2014; 29(2):367-370. DOI: 10.1111/jdv.12556. View

Baz K, Cimen M, Kokturk A, Aslan G, Ikizoglu G, Demirseren D . Plasma reactive oxygen species activity and antioxidant potential levels in rosacea patients: correlation with seropositivity to Helicobacter pylori. Int J Dermatol. 2004; 43(7):494-7. DOI: 10.1111/j.1365-4632.2004.02137.x. View

Gurer M, Erel A, Erbas D, Caglar K, Atahan C . The seroprevalence of Helicobacter pylori and nitric oxide in acne rosacea. Int J Dermatol. 2002; 41(11):768-70. DOI: 10.1046/j.1365-4362.2002.01452.x. View

Yazici A, Tamer L, Ikizoglu G, Kaya T, Api H, Yildirim H . GSTM1 and GSTT1 null genotypes as possible heritable factors of rosacea. Photodermatol Photoimmunol Photomed. 2006; 22(4):208-10. DOI: 10.1111/j.1600-0781.2006.00220.x. View

10.

Jones D . Rosacea, reactive oxygen species, and azelaic Acid. J Clin Aesthet Dermatol. 2010; 2(1):26-30. PMC: 2958186. View

11.

Sredoja Tisma V, Basta-Juzbasic A, Jaganjac M, Brcic L, Dobric I, Lipozencic J . Oxidative stress and ferritin expression in the skin of patients with rosacea. J Am Acad Dermatol. 2008; 60(2):270-6. DOI: 10.1016/j.jaad.2008.10.014. View

12.

Woo Y, Lim J, Cho D, Park H . Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition. Int J Mol Sci. 2016; 17(9). PMC: 5037831. DOI: 10.3390/ijms17091562. View

13.

Oztas M, Balk M, Ogus E, Bozkurt M, Ogus I, Ozer N . The role of free oxygen radicals in the aetiopathogenesis of rosacea. Clin Exp Dermatol. 2003; 28(2):188-92. DOI: 10.1046/j.1365-2230.2003.01179.x. View