New Insights on the Pathogenesis of Endometriosis and Novel Non-surgical Therapies

Overview

Journal J Turk Ger Gynecol Assoc

Publisher Galenos Publishing House

Specialty Gynecology & Obstetrics

Date 2018 Jul 17

PMID 30008440

Citations 6

Authors

Anom Suardika

Tjokorda Gede Astawa Pemayun

Affiliations

Soon will be listed here.

Abstract

Endometriosis is a disease of theories, but none has succeeded to explain the whole picture. Most widely available drugs for endometriosis aim to relieve symptoms and improve fertility. Unfortunately, many short and long-term side-effects are associated with the treatments. To overcome this problem, researchers have developed many novel therapeutic agents, including non-invasive technique. We aim to provide new insights on pathogenesis model and novel non-surgical treatments for endometriosis, including drugs already available in the market and also drugs which are still under research. Seven novel treatment modalities are recognized, namely dienogest, aromatase inhibitor (AI), gonadotrophine-releasing hormone (GnRH) antagonist, anti tumor necrosing factor (TNF)-α, selective estrogen receptor modulator (SERM), selective progesterone receptor modulator (SPRM), and high-intensity focused ultrasound (HIFU). Dienogest, AI, and GnRH antagonists are effective novel treatments with good tolerance and safety. SERM and SPRM show inconsistent results, while anti-TNF-α is still in the animal experimental stage. HIFU is a potential futuristic treatment. However, it is still a long way until this technology is truly applicable.

Citing Articles

Role of Pink1-mediated mitophagy in adenomyosis.

Chen M, Wang W, Fu X, Yi Y, Wang K, Wang M PeerJ. 2023; 11:e16497.

PMID: 38050606 PMC: 10693823. DOI: 10.7717/peerj.16497.

Evaluating the Phagocytic Index of Peripheral Leukocytes in Endometriosis by Plasma Experiments.

Lukacs L, Kovacs A, Pal L, Szucs S, Lampe R Medicina (Kaunas). 2022; 58(7).

PMID: 35888644 PMC: 9316155. DOI: 10.3390/medicina58070925.

Integrating Network Pharmacology and Experimental Validation Deciphers the Mechanism of Guizhi Fuling Wan against Adenomyosis.

Wang H, Zhang J, Zhu Q, Fu X, Li C Evid Based Complement Alternat Med. 2021; 2021:6034147.

PMID: 34737779 PMC: 8563128. DOI: 10.1155/2021/6034147.

The Role of Abnormal Uterine Junction Zone in the Occurrence and Development of Adenomyosis.

Xie T, Xu X, Yang Y, Wu C, Liu X, Zhou L Reprod Sci. 2021; 29(10):2719-2730.

PMID: 34515984 DOI: 10.1007/s43032-021-00684-2.

Bioinformatics Analysis Identifies Molecular Markers Regulating Development and Progression of Endometriosis and Potential Therapeutic Drugs.

Peng Y, Peng C, Fang Z, Chen G Front Genet. 2021; 12:622683.

PMID: 34421979 PMC: 8372410. DOI: 10.3389/fgene.2021.622683.

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