Epoxygenase Inhibitors Attenuate the Stimulatory Effect of Glutoxim on Na Transport in Frog Skin

Overview

Journal Dokl Biochem Biophys

Specialties Biochemistry
Biophysics

Date 2018 Jul 16

PMID 30008098

Authors

Z I Krutetskaya

A V Melnitskaya

V G Antonov

A D Nozdrachev

Affiliations

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Abstract

Using voltage-clamp technique, the involvement of epoxygenases in immunomodulatory drug glutoxim regulation of Na transport in frog skin was investigated. We have shown for the first time that preincubation of the frog skin with epoxygenase inhibitors econazole or proadifen almost completely inhibits the stimulatory effect of glutoxim on Na transport. The data suggest the involvement of the enzymes and/or products of epoxygenase oxidation pathway of arachidonic acid metabolism in glutoxim effect on Na transport in frog skin epithelium.

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