Gliomatosis Cerebri: a Consensus Summary Report from the Second International Gliomatosis Cerebri Group Meeting, June 22-23, 2017, Bethesda, USA

Overview

Journal J Neurooncol

Publisher Springer

Date 2018 Jul 13

PMID 29998396

Citations 5

Authors

Andres Morales La Madrid

Surabhi Ranjan

Katherine E Warren

Affiliations

Soon will be listed here.

Abstract

Gliomatosis cerebri (GC) is an aggressive glioma characterized by an invasive growth pattern and a dismal prognosis. The low incidence and non-specific symptoms at presentation pose unique challenges for early diagnosis and disease-specific research. There is no standard of care for the treatment of patients with a GC phenotype. Understanding the biology of this entity is a critical step in determining effective treatments. Toward this end, the Second International GC Group convened at National Institutes of Health, Bethesda on June 22nd-23rd 2017. This paper summarizes the main conclusions and recommendations for research priorities to fight this fatal condition.

Citing Articles

Gliomatosis cerebri (GC) growth pattern: A single-center analysis of clinical, histological, and molecular characteristics of GC and non-GC glioblastoma.

Dive I, Weber K, Hartung T, Steidl E, Wagner M, Hattingen E Neurooncol Adv. 2023; 5(1):vdad131.

PMID: 38024242 PMC: 10676054. DOI: 10.1093/noajnl/vdad131.

Leber's hereditary optic neuropathy with diffuse white matter changes mimicking gliomatosis cerebri: illustrative case.

Saruta W, Shibahara I, Handa H, Inukai M, Kanayama S, Yasumoto R J Neurosurg Case Lessons. 2022; 1(26):CASE21161.

PMID: 35854899 PMC: 9245756. DOI: 10.3171/CASE21161.

Branch-like enhancement on contrast enhanced MRI is a specific finding of cerebellar lymphoma compared with other pathologies.

Yokoyama K, Oyama J, Tsuchiya J, Karakama J, Tamura K, Inaji M Sci Rep. 2022; 12(1):3591.

PMID: 35246572 PMC: 8897486. DOI: 10.1038/s41598-022-07581-x.

A rare case of gliomatosis cerebri lurking beneath the shadows of a stroke mimic.

Prasad A, Hurlburt G, Van Antwerp E, Srivastava S, Sriwastava S Radiol Case Rep. 2021; 16(9):2701-2705.

PMID: 34345333 PMC: 8319009. DOI: 10.1016/j.radcr.2021.06.060.

Treatment Strategies Based on Histological Targets against Invasive and Resistant Glioblastoma.

Hara A, Kanayama T, Noguchi K, Niwa A, Miyai M, Kawaguchi M J Oncol. 2019; 2019:2964783.

PMID: 31320900 PMC: 6610731. DOI: 10.1155/2019/2964783.

References

DUrso O, DUrso P, Marsigliante S, Storelli C, Luzi G, Damiano Gianfreda C . Correlative analysis of gene expression profile and prognosis in patients with gliomatosis cerebri. Cancer. 2009; 115(16):3749-57. DOI: 10.1002/cncr.24435. View

Kalbasi A, June C, Haas N, Vapiwala N . Radiation and immunotherapy: a synergistic combination. J Clin Invest. 2013; 123(7):2756-63. PMC: 4101987. DOI: 10.1172/JCI69219. View

Ruda R, Bertero L, Sanson M . Gliomatosis cerebri: a review. Curr Treat Options Neurol. 2014; 16(2):273. DOI: 10.1007/s11940-013-0273-2. View

Mawrin C, von Mawrin A, Kirches E, Schneider-Stock R, Boltze C, Vorwerk C . Alterations of cell cycle regulators in gliomatosis cerebri. J Neurooncol. 2005; 72(2):115-22. DOI: 10.1007/s11060-004-2061-z. View

Broniscer A, Chamdine O, Hwang S, Lin T, Pounds S, Onar-Thomas A . Gliomatosis cerebri in children shares molecular characteristics with other pediatric gliomas. Acta Neuropathol. 2016; 131(2):299-307. PMC: 4886851. DOI: 10.1007/s00401-015-1532-y. View

Herrlinger U, Jones D, Glas M, Hattingen E, Gramatzki D, Stuplich M . Gliomatosis cerebri: no evidence for a separate brain tumor entity. Acta Neuropathol. 2015; 131(2):309-319. DOI: 10.1007/s00401-015-1495-z. View

Taillibert S, Chodkiewicz C, Laigle-Donadey F, Napolitano M, Cartalat-Carel S, Sanson M . Gliomatosis cerebri: a review of 296 cases from the ANOCEF database and the literature. J Neurooncol. 2005; 76(2):201-5. DOI: 10.1007/s11060-005-5263-0. View

Chen S, Tanaka S, Giannini C, Morris J, Yan E, Buckner J . Gliomatosis cerebri: clinical characteristics, management, and outcomes. J Neurooncol. 2013; 112(2):267-75. PMC: 3907195. DOI: 10.1007/s11060-013-1058-x. View

Glas M, Bahr O, Felsberg J, Rasch K, Wiewrodt D, Schabet M . NOA-05 phase 2 trial of procarbazine and lomustine therapy in gliomatosis cerebri. Ann Neurol. 2011; 70(3):445-53. DOI: 10.1002/ana.22478. View

10.

Ranjan S, Warren K . Gliomatosis Cerebri: Current Understanding and Controversies. Front Oncol. 2017; 7:165. PMC: 5545748. DOI: 10.3389/fonc.2017.00165. View

11.

Carroll K, Hirshman B, Ali M, Alattar A, Brandel M, Lochte B . Management and Survival Patterns of Patients with Gliomatosis Cerebri: A SEER-Based Analysis. World Neurosurg. 2017; 103:186-193. DOI: 10.1016/j.wneu.2017.03.103. View

12.

Kleihues P, Burger P, Scheithauer B . The new WHO classification of brain tumours. Brain Pathol. 1993; 3(3):255-68. DOI: 10.1111/j.1750-3639.1993.tb00752.x. View

13.

George E, Settler A, Connors S, Greenfield J . Pediatric Gliomatosis Cerebri: A Review of 15 Years. J Child Neurol. 2015; 31(3):378-87. DOI: 10.1177/0883073815596612. View

14.

Inoue T, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Tominaga T . Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases. Neurosurg Rev. 2011; 34(2):197-208. DOI: 10.1007/s10143-010-0306-1. View

15.

Greenfield J, Castaneda Heredia A, George E, Kieran M, Morales La Madrid A . Gliomatosis cerebri: A consensus summary report from the First International Gliomatosis cerebri Group Meeting, March 26-27, 2015, Paris, France. Pediatr Blood Cancer. 2016; 63(12):2072-2077. DOI: 10.1002/pbc.26169. View

16.

Patel K, Lawson D, Kudchadkar R, Carthon B, Oliver D, Okwan-Duodu D . Two heads better than one? Ipilimumab immunotherapy and radiation therapy for melanoma brain metastases. Neuro Oncol. 2015; 17(10):1312-21. PMC: 4578585. DOI: 10.1093/neuonc/nov093. View

17.

Sanson M, Cartalat-Carel S, Taillibert S, Napolitano M, Djafari L, Cougnard J . Initial chemotherapy in gliomatosis cerebri. Neurology. 2004; 63(2):270-5. DOI: 10.1212/01.wnl.0000129985.39973.e4. View

18.

Louis D, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee W . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016; 131(6):803-20. DOI: 10.1007/s00401-016-1545-1. View