The Melanin-concentrating Hormone System in Human, Rodent and Avian Brain

Overview

Journal Open Med (Wars)

Specialty General Medicine

Date 2018 Jul 12

PMID 29992190

Citations 3

Authors

Janos Bencze

Krisztina Pocsai

Balazs Murnyak

Peter Attila Gergely

Bela Juhasz

Zoltan Szilvassy

Tibor Hortobagyi

Affiliations

Soon will be listed here.

Abstract

Melanin-concentrating hormone (MCH) is a cyclic 19 amino acid orexigenic hypothalamic peptide. MCH is located in the lateral and dorsal hypothalamus, as well as in the zona incerta. In mammals MCH increases food intake, contributes to regulation of energy balance, temperature, reproductive function, endocrine homeostasis and biological rhythms. Several studies have proved the significance of MCH in obesity, diabetes and depression. Although the peptide is well-characterized in mouse models, much less is known about its functions in avians. In birds the MCH system especially in the lateral and basal hypothalamus has important connections to the limbic system and it coordinates the vegetative and endocrine functions, as well as the emotional behaviour. Pharmacological modulation of MCH system could contribute to the therapy of eating disorders and improve agricultural efficiency regarding avians. Reviewing the current knowledge on MCH system in human, rodents and avians may stimulate a new wave of studies in the field.

Citing Articles

Chronic Stress-Induced Elevation of Melanin-Concentrating Hormone in the Locus Coeruleus Inhibits Norepinephrine Production and Associated With Depression-Like Behaviors in Rats.

Kurban N, Qin Y, Zhao H, Hu X, Chen X, Zhao Y Int J Neuropsychopharmacol. 2023; 27(1).

PMID: 38135278 PMC: 10799331. DOI: 10.1093/ijnp/pyad069.

Anxiety and Depression: What Do We Know of Neuropeptides?.

Kupcova I, Danisovic L, Grgac I, Harsanyi S Behav Sci (Basel). 2022; 12(8).

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Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in Rodents.

Oh J, Liu Q, Hua C, Jeong H, Jang J, Jeon S Exp Neurobiol. 2020; 29(6):453-469.

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