Sharing More Than Friendship - Transmission of NDM-5 ST167 and CTX-M-9 ST69 Between Dogs and Humans in a Family, Finland, 2015

Overview

Journal Euro Surveill

Specialty Infectious Diseases

Date 2018 Jul 12

PMID 29991384

Citations 73

Authors

Thomas Gronthal

Monica Osterblad

Marjut Eklund

Jari Jalava

Suvi Nykasenoja

Katariina Pekkanen

Merja Rantala

Affiliations

Soon will be listed here.

Abstract

IntroductionCarbapenemase-producing (CPE) have rarely been reported in dogs, and never in animals in Finland. However, in April 2015, two meropenem-resistant were identified from two dogs in one family. Both dogs suffered from chronic . Epidemiological and molecular investigations (pulsed-field gel electrophoresis (PFGE), multilocus sequence typing) were conducted to investigate the source of infection and transmission routes. In both dogs and one family member New Delhi metallo-beta-lactamase (NDM-5)-producing multidrug-resistant ST167 was found. Whole genome sequencing confirmed that the isolates were identical or only had one or two allelic differences. Additionally, the dogs and humans of the family carried an identical extended-spectrum beta-lactamase (ESBL) CTX-M-group 9 ST69 strain, indicating interspecies transmission. While the original source remains unclear, human-to-canine transmission is possible. No carbapenems had been administered to the dogs, but exposure to numerous other antimicrobials likely sustained the bacteria and supported its propagation in the canine host. To our knowledge, canine clinical NDM-5 in Europe, and confirmed CPE transmission between dogs and humans have not been previously reported. The screening of veterinary isolates for carbapenem resistance is highly recommended.

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