Effects of Particulate Matter on Allergic Respiratory Diseases

Overview

Journal Chronic Dis Transl Med

Publisher Wiley

Date 2018 Jul 11

PMID 29988900

Citations 38

Authors

Jin-Zhun Wu

Dan-Dan Ge

Lin-Fu Zhou

Ling-Yun Hou

Ying Zhou

Qi-Yuan Li

Affiliations

Soon will be listed here.

Abstract

The health impact of airborne particulate matter (PM) has long been a concern to clinicians, biologists, and the general public. With many epidemiological studies confirming the association of PM with allergic respiratory diseases, an increasing number of follow-up empirical studies are being conducted to investigate the mechanisms underlying the toxic effects of PM on asthma and allergic rhinitis. In this review, we have briefly introduced the characteristics of PM and discussed its effects on public health. Subsequently, we have focused on recent studies to elucidate the association between PM and the allergic symptoms of human respiratory diseases. Specifically, we have discussed the mechanism of action of PM in allergic respiratory diseases according to different subtypes: coarse PM (PM), fine PM (PM), and ultrafine PM.

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References

Li X, Gilmour P, Donaldson K, MacNee W . In vivo and in vitro proinflammatory effects of particulate air pollution (PM10). Environ Health Perspect. 1997; 105 Suppl 5:1279-83. PMC: 1470161. DOI: 10.1289/ehp.97105s51279. View

Hultner L, Druez C, Moeller J, Uyttenhove C, Schmitt E, Rude E . Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9). Eur J Immunol. 1990; 20(6):1413-6. DOI: 10.1002/eji.1830200632. View

Terada N, Hamano N, Maesako K, Hiruma K, Hohki G, Suzuki K . Diesel exhaust particulates upregulate histamine receptor mRNA and increase histamine-induced IL-8 and GM-CSF production in nasal epithelial cells and endothelial cells. Clin Exp Allergy. 1999; 29(1):52-9. DOI: 10.1046/j.1365-2222.1999.00406.x. View

Guo Z, Dong W, Xu J, Hong Z, Zhao R, Deng C . T-helper type 1-T-helper type 2 shift and nasal remodeling after fine particulate matter exposure in a rat model of allergic rhinitis. Am J Rhinol Allergy. 2017; 31(3):148-155. DOI: 10.2500/ajra.2017.31.4437. View

Bradding P, Walls A, Holgate S . The role of the mast cell in the pathophysiology of asthma. J Allergy Clin Immunol. 2006; 117(6):1277-84. DOI: 10.1016/j.jaci.2006.02.039. View

Jo E, Lee W, Jo H, Kim C, Eom J, Mok J . Effects of particulate matter on respiratory disease and the impact of meteorological factors in Busan, Korea. Respir Med. 2017; 124:79-87. DOI: 10.1016/j.rmed.2017.02.010. View

Ozturk A, Bayraktar R, Gogebakan B, Mumbuc S, Bayram H . Comparison of inflammatory cytokine release from nasal epithelial cells of non-atopic non-rhinitic, allergic rhinitic and polyp subjects and effects of diesel exhaust particles in vitro. Allergol Immunopathol (Madr). 2017; 45(5):473-481. DOI: 10.1016/j.aller.2016.10.015. View

Ying S, Durham S, Jacobson M, Rak S, Masuyama K, Lowhagen O . T lymphocytes and mast cells express messenger RNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis. Immunology. 1994; 82(2):200-6. PMC: 1414815. View

Kim H, Bouchard J, Renzi P . The link between allergic rhinitis and asthma: a role for antileukotrienes?. Can Respir J. 2008; 15(2):91-8. PMC: 2677841. DOI: 10.1155/2008/416095. View

10.

Robinson D . The role of the T cell in asthma. J Allergy Clin Immunol. 2010; 126(6):1081-91. DOI: 10.1016/j.jaci.2010.06.025. View

11.

Alexis N, Huang Y, Rappold A, Kehrl H, Devlin R, Peden D . Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter. Am J Respir Crit Care Med. 2014; 190(2):235-7. PMC: 4226054. DOI: 10.1164/rccm.201401-0126LE. View

12.

Uh S, Koo S, Kim Y, Kim K, Park S, Jang A . The activation of NLRP3-inflammsome by stimulation of diesel exhaust particles in lung tissues from emphysema model and RAW 264.7 cell line. Korean J Intern Med. 2017; 32(5):865-874. PMC: 5583452. DOI: 10.3904/kjim.2016.033. View

13.

Kobayashi T, Ikeue T, Ito T, Ikeda A, Murakami M, Kato A . Short-term exposure to diesel exhaust induces nasal mucosal hyperresponsiveness to histamine in guinea pigs. Fundam Appl Toxicol. 1997; 38(2):166-72. DOI: 10.1006/faat.1997.2347. View

14.

McGee M, Kamal A, McGee J, Wood C, Dye J, Krantz Q . Differential effects of particulate matter upwind and downwind of an urban freeway in an allergic mouse model. Environ Sci Technol. 2015; 49(6):3930-9. DOI: 10.1021/es506048k. View

15.

Aalapati S, Ganapathy S, Manapuram S, Anumolu G, Prakya B . Toxicity and bio-accumulation of inhaled cerium oxide nanoparticles in CD1 mice. Nanotoxicology. 2013; 8(7):786-98. DOI: 10.3109/17435390.2013.829877. View

16.

Mazenq J, Dubus J, Gaudart J, Charpin D, Nougairede A, Viudes G . Air pollution and children's asthma-related emergency hospital visits in southeastern France. Eur J Pediatr. 2017; 176(6):705-711. DOI: 10.1007/s00431-017-2900-5. View

17.

Kobayashi T, Ito T . Diesel exhaust particulates induce nasal mucosal hyperresponsiveness to inhaled histamine aerosol. Fundam Appl Toxicol. 1995; 27(2):195-202. DOI: 10.1006/faat.1995.1124. View

18.

Fann N, Lamson A, Anenberg S, Wesson K, Risley D, Hubbell B . Estimating the national public health burden associated with exposure to ambient PM2.5 and ozone. Risk Anal. 2011; 32(1):81-95. DOI: 10.1111/j.1539-6924.2011.01630.x. View

19.

Tian Y, Xiang X, Juan J, Sun K, Song J, Cao Y . Fine particulate air pollution and hospital visits for asthma in Beijing, China. Environ Pollut. 2017; 230:227-233. DOI: 10.1016/j.envpol.2017.06.029. View

20.

Wilson W, Suh H . Fine particles and coarse particles: concentration relationships relevant to epidemiologic studies. J Air Waste Manag Assoc. 1998; 47(12):1238-49. DOI: 10.1080/10473289.1997.10464074. View