The Current Role and Future Prospectives of Functional Parameters by Diffusion Weighted Imaging in the Assessment of Histologic Grade of HCC

Overview

Journal Infect Agent Cancer

Publisher Biomed Central

Specialty Infectious Diseases

Date 2018 Jul 11

PMID 29988667

Citations 34

Authors

Vincenza Granata

Roberta Fusco

Salvatore Filice

Orlando Catalano

Mauro Piccirillo

Raffaele Palaia

Francesco Izzo

Antonella Petrillo

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.

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