Silver-catalyzed Remote Csp-H Functionalization of Aliphatic Alcohols

Overview

Journal Nat Commun

Specialty Biology

Date 2018 Jul 8

PMID 29980674

Citations 14

Authors

Yuchao Zhu

Kaimeng Huang

Jun Pan

Xu Qiu

Xiao Luo

Qixue Qin

Jialiang Wei

Xiaojin Wen

Lizhi Zhang

Ning Jiao

Affiliations

Soon will be listed here.

Abstract

Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic alcohols is attractive but challenging. Herein, we report a silver-catalyzed δ-selective Csp-H bond functionalization of abundant and inexpensive aliphatic alcohols. Valuable oximonitrile substituted alcohols are easily obtained by using well-designed sulphonyl reagents under simple and mild conditions. This protocol realizes the challenging δ-selective C-C bond formation of simple alkanols.

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