F-NaF and F-FDG As Molecular Probes in the Evaluation of Atherosclerosis

Overview

Journal Eur J Nucl Med Mol Imaging

Specialties Biophysics
Nuclear Medicine
Radiology

Date 2018 Jul 7

PMID 29978245

Citations 58

Authors

Mikaela L McKenney-Drake

Mateen C Moghbel

Koosha Paydary

Mouhamad Alloosh

Sina Houshmand

Sharon Moe

Ali Salavati

Jeffrey M Sturek

Paul R Territo

Connie Weaver

Thomas J Werner

Poul Flemming Hoilund-Carlsen

Michael Sturek

Abass Alavi

Affiliations

Soon will be listed here.

Abstract

The early detection of atherosclerotic disease is vital to the effective prevention and management of life-threatening cardiovascular events such as myocardial infarctions and cerebrovascular accidents. Given the potential for positron emission tomography (PET) to visualize atherosclerosis earlier in the disease process than anatomic imaging modalities such as computed tomography (CT), this application of PET imaging has been the focus of intense scientific inquiry. Although F-FDG has historically been the most widely studied PET radiotracer in this domain, there is a growing body of evidence that F-NaF holds significant diagnostic and prognostic value as well. In this article, we review the existing literature on the application of F-FDG and F-NaF as PET probes in atherosclerosis and present the findings of original animal and human studies that have examined how well F-NaF uptake correlates with vascular calcification and cardiovascular risk.

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References

Paulmier B, Duet M, Khayat R, Pierquet-Ghazzar N, Laissy J, Maunoury C . Arterial wall uptake of fluorodeoxyglucose on PET imaging in stable cancer disease patients indicates higher risk for cardiovascular events. J Nucl Cardiol. 2008; 15(2):209-17. DOI: 10.1016/j.nuclcard.2007.10.009. View

Nakahara T, Strauss H . From inflammation to calcification in atherosclerosis. Eur J Nucl Med Mol Imaging. 2017; 44(5):858-860. DOI: 10.1007/s00259-016-3608-x. View

Irkle A, Vesey A, Lewis D, Skepper J, Bird J, Dweck M . Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography. Nat Commun. 2015; 6:7495. PMC: 4506997. DOI: 10.1038/ncomms8495. View

Puri R, Nicholls S, Shao M, Kataoka Y, Uno K, Kapadia S . Impact of statins on serial coronary calcification during atheroma progression and regression. J Am Coll Cardiol. 2015; 65(13):1273-1282. DOI: 10.1016/j.jacc.2015.01.036. View

Derlin T, Toth Z, Papp L, Wisotzki C, Apostolova I, Habermann C . Correlation of inflammation assessed by 18F-FDG PET, active mineral deposition assessed by 18F-fluoride PET, and vascular calcification in atherosclerotic plaque: a dual-tracer PET/CT study. J Nucl Med. 2011; 52(7):1020-7. DOI: 10.2967/jnumed.111.087452. View

Derlin T, Wisotzki C, Richter U, Apostolova I, Bannas P, Weber C . In vivo imaging of mineral deposition in carotid plaque using 18F-sodium fluoride PET/CT: correlation with atherogenic risk factors. J Nucl Med. 2011; 52(3):362-8. DOI: 10.2967/jnumed.110.081208. View

McEvoy J, Blaha M, DeFilippis A, Budoff M, Nasir K, Blumenthal R . Coronary artery calcium progression: an important clinical measurement? A review of published reports. J Am Coll Cardiol. 2010; 56(20):1613-22. DOI: 10.1016/j.jacc.2010.06.038. View

Bucerius J, Schmaljohann J, Bohm I, Palmedo H, Guhlke S, Tiemann K . Feasibility of 18F-fluoromethylcholine PET/CT for imaging of vessel wall alterations in humans--first results. Eur J Nucl Med Mol Imaging. 2008; 35(4):815-20. DOI: 10.1007/s00259-007-0685-x. View

Rominger A, Saam T, Wolpers S, Cyran C, Schmidt M, Foerster S . 18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease. J Nucl Med. 2009; 50(10):1611-20. DOI: 10.2967/jnumed.109.065151. View

10.

Marnane M, Merwick A, Sheehan O, Hannon N, Foran P, Grant T . Carotid plaque inflammation on 18F-fluorodeoxyglucose positron emission tomography predicts early stroke recurrence. Ann Neurol. 2012; 71(5):709-18. DOI: 10.1002/ana.23553. View

11.

Lloyd-Jones D, Adams R, Carnethon M, de Simone G, Ferguson T, Flegal K . Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008; 119(3):e21-181. DOI: 10.1161/CIRCULATIONAHA.108.191261. View

12.

Worthley S, Zhang Z, Machac J, Helft G, Tang C, Liew G . In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis. Int J Cardiovasc Imaging. 2008; 25(3):251-7. DOI: 10.1007/s10554-008-9377-2. View

13.

Morbelli S, Fiz F, Piccardo A, Picori L, Massollo M, Pestarino E . Divergent determinants of 18F-NaF uptake and visible calcium deposition in large arteries: relationship with Framingham risk score. Int J Cardiovasc Imaging. 2013; 30(2):439-47. DOI: 10.1007/s10554-013-0342-3. View

14.

Neeb Z, Edwards J, Alloosh M, Long X, Mokelke E, Sturek M . Metabolic syndrome and coronary artery disease in Ossabaw compared with Yucatan swine. Comp Med. 2010; 60(4):300-15. PMC: 2930329. View

15.

Bural G, Torigian D, Chamroonrat W, Alkhawaldeh K, Houseni M, El-Haddad G . Quantitative assessment of the atherosclerotic burden of the aorta by combined FDG-PET and CT image analysis: a new concept. Nucl Med Biol. 2006; 33(8):1037-43. DOI: 10.1016/j.nucmedbio.2006.08.005. View

16.

Janssen T, Bannas P, Herrmann J, Veldhoen S, Busch J, Treszl A . Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: a PET/CT study. J Nucl Cardiol. 2013; 20(4):569-77. DOI: 10.1007/s12350-013-9680-8. View

17.

Chen W, Dilsizian V . Targeted PET/CT imaging of vulnerable atherosclerotic plaques: microcalcification with sodium fluoride and inflammation with fluorodeoxyglucose. Curr Cardiol Rep. 2013; 15(6):364. DOI: 10.1007/s11886-013-0364-4. View

18.

Wykrzykowska J, Lehman S, Williams G, Parker J, Palmer M, Varkey S . Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET/CT in patients with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation. J Nucl Med. 2009; 50(4):563-8. DOI: 10.2967/jnumed.108.055616. View

19.

Williams G, Kolodny G . Suppression of myocardial 18F-FDG uptake by preparing patients with a high-fat, low-carbohydrate diet. AJR Am J Roentgenol. 2008; 190(2):W151-6. DOI: 10.2214/AJR.07.2409. View

20.

Steinl D, Kaufmann B . Ultrasound imaging for risk assessment in atherosclerosis. Int J Mol Sci. 2015; 16(5):9749-69. PMC: 4463615. DOI: 10.3390/ijms16059749. View