The Relation Between Pregnancy-Associated Plasma Protein A and Obstructive Sleep Apnea Syndrome

Overview

Journal Can Respir J

Publisher Wiley

Specialty Pulmonary Medicine

Date 2018 Jul 6

PMID 29973962

Citations 3

Authors

Ali Cengiz

Suat Konuk

Tuncer Tug

Affiliations

Soon will be listed here.

Abstract

Aim: We aimed to investigate the relationship between serum pregnancy-associated plasma protein A (PAPP-A) levels and obstructive sleep apnea syndrome (OSAS).

Materials And Method: 44 patients with OSAS and 44 healthy adults were included in this study. The participants having rheumatic or systemic inflammatory disease, advanced liver or kidney failure, diabetes, heart failure, hypertension, pregnancy, prerenal azotemia, known history of coronary artery disease, any pulmonary disease, rhinitis, or atopy, history of major trauma or surgery within the last six 6 months, and inhaled nasal or systemic corticosteroid use or other anti-inflammatory medications and those with <18 years of age were excluded. Serum PAPP-A levels were determined by the Elisa method with the immune sandwich measuring method. Statistical analysis of the study was performed with SPSS 17.0 statistical analysis package program, and < 0.05 was considered as significant.

Results: Serum PAPP-A levels of patients with OSAS (2.350 ng/ml (0.641-4.796)) were significantly higher ( < 0.001) when compared with healthy controls (0.971 ng/ml (0.109-2.679)). There was a statistically significant difference in serum PAPP-A levels between groups of OSAS patients according to the classification of OSAS severity. Between the groups of patients with OSAS, serum levels of PAPP-A in moderate group was significantly higher when compared with severe OSAS group ( < 0.001). There was positive correlations between PAPP-A levels and night minimum (=0.042, =0.309), and average oxygen levels (=0.006, =0.407). There was a negative correlation between PAPP-A levels and AHI (=0.002, =-0.460).

Conclusion: Higher PAPP-A levels in OSAS patients that were found in this study show inflammatory component in OSAS.

Citing Articles

Oxidative Stress Markers among Obstructive Sleep Apnea Patients.

Stanek A, Brozyna-Tkaczyk K, Myslinski W Oxid Med Cell Longev. 2021; 2021:9681595.

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Evaluation of Blood Levels of C-Reactive Protein Marker in Obstructive Sleep Apnea: A Systematic Review, Meta-Analysis and Meta-Regression.

Imani M, Sadeghi M, Farokhzadeh F, Khazaie H, Brand S, Dursteler K Life (Basel). 2021; 11(4).

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Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls.

Frank B, Khailova L, Silveira L, Mitchell M, Morgan G, Hsieh E Transl Res. 2020; 229:24-37.

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