Expression and Network Analysis of YBX1 Interactors for Identification of New Drug Targets in Lung Adenocarcinoma

Overview

Journal J Genomics

Specialty Genetics

Date 2018 Jul 6

PMID 29973960

Citations 8

Authors

Suriya Narayanan Murugesan

Birendra Singh Yadav

Pramod Kumar Maurya

Amit Chaudhary

Swati Singh

Ashutosh Mani

Affiliations

Soon will be listed here.

Abstract

Y-Box Binding protein 1 (YBX-1) is known to be involved in various types of cancers. It's interactors also play major role in various cellular functions. Present work aimed to study the expression profile of the YBX-1 interactors during lung adenocarcinoma (LUAD). The differential expression analysis involved 57 genes from 95 lung adenocarcinoma samples, construction of gene network and topology analysis. A Total of 43 genes were found to be differentially expressed from which 17 genes were found to be down regulated and 26 genes were up-regulated. We observed that Polyadenylate-binding protein 1 (PABPC1), a protein involved in YBX1 translation, is highly correlated with YBX1. The interaction network analysis for a differentially expressed non-coding RNA Growth Arrest Specific 5 (GAS5) suggests that two proteins namely, Growth Arrest Specific 2 (GAS2) and Peripheral myelin protein 22 (PMP22) are potentially involved in LUAD progression. The network analysis and differential expression suggests that Collagen type 1 alpha 2 (COL1A2) can be potential biomarker and target for LUAD.

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