Molecular Regulation of Histamine Synthesis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Jul 6

PMID 29973935

Citations 44

Authors

Hua Huang

Yapeng Li

Jinyi Liang

Fred D Finkelman

Affiliations

Soon will be listed here.

Abstract

Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Despite the importance of histamine, transcriptional regulation of gene expression in mammals is still poorly understood. In this review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis.

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