Systemic-inflammation-based Score Can Predict Prognosis in Metastatic Gastric Cancer Patients Before First-line Chemotherapy

Overview

Journal Future Oncol

Specialty Oncology

Date 2018 Jul 4

PMID 29969285

Citations 14

Authors

Angelica Petrillo

Maria Maddalena Laterza

Giuseppe Tirino

Luca Pompella

Jole Ventriglia

Annalisa Pappalardo

Vincenzo Famiglietti

Erika Martinelli

Fortunato Ciardiello

Michele Orditura

Gennaro Galizia

Ferdinando De Vita

Affiliations

Soon will be listed here.

Abstract

Aim: Systemic inflammatory response affects survival of gastric cancer (GC) patients. This study was carried out to create a prognostic inflammatory-based score to predict survival in metastatic GC (mGC) before first-line chemotherapy.

Materials & Methods: We studied the prognostic value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio in 151 patients with mGC at the diagnosis.

Results: Median overall survival (OS) was significantly lower in patients with high NLR. Performance status 1-2 according to the Eastern Cooperative Oncology Group scale and NLR were predictors of shorter OS at multivariate analysis. Based on these results, we defined a prognostic OS score, showing a better median OS in favorable risk group.

Conclusion: Elevated pretreatment NLR and Eastern Cooperative Oncology Group are independent predictors of shorter OS in mGC patients before first-line chemotherapy.

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