Advanced Physical Techniques for Gene Delivery Based on Membrane Perforation

Overview

Journal Drug Deliv

Specialty Pharmacology

Date 2018 Jul 4

PMID 29968512

Citations 34

Authors

Xiaofan Du

Jing Wang

Quan Zhou

Luwei Zhang

Sijia Wang

Zhenxi Zhang

Cuiping Yao

Affiliations

Soon will be listed here.

Abstract

Gene delivery as a promising and valid tool has been used for treating many serious diseases that conventional drug therapies cannot cure. Due to the advancement of physical technology and nanotechnology, advanced physical gene delivery methods such as electroporation, magnetoporation, sonoporation and optoporation have been extensively developed and are receiving increasing attention, which have the advantages of briefness and nontoxicity. This review introduces the technique detail of membrane perforation, with a brief discussion for future development, with special emphasis on nanoparticles mediated optoporation that have developed as an new alternative transfection technique in the last two decades. In particular, the advanced physical approaches development and new technology are highlighted, which intends to stimulate rapid advancement of perforation techniques, develop new delivery strategies and accelerate application of these techniques in clinic.

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